family_id: PANTHER:PTHR16515
family_name: PR DOMAIN ZINC FINGER PROTEIN
preferred_name: Diverse C2H2 zinc-finger regulatory proteins
summary: This broad group contains multiple zinc-finger transcription regulators, including Krueppel-like
  proteins, PLAG proteins and PRDM proteins. Some branches carry additional chromatin-regulatory domains,
  whereas others primarily recognize DNA through zinc-finger arrays. Drosophila Dati has a demonstrated
  role in specific neuronal circuits, but this behavior is not a family-wide property.
functional_coherence: HETEROGENEOUS
coherence_reason: Shared C2H2 zinc fingers span PRDM, KLF-like and other transcriptional regulators with
  different auxiliary domains and DNA targets. Fly dati genetics localizes female receptivity and locomotion
  phenotypes to distinguishable neuronal circuits, including a cholinergic requirement for receptivity
  (PMID:25291190). This supports a neuronal transcription-regulatory context for DATI, not a family-wide
  behavioral function. PR-domain-dependent histone methylation cannot be assigned to all zinc-finger members
  or to DATI merely from the broad family name.
subfamilies:
- subfamily_id: PANTHER:PTHR16515:SF49
  label: GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED
  description: Shared C2H2 zinc fingers span PRDM, KLF-like and other transcriptional regulators with
    different auxiliary domains and DNA targets. Fly dati genetics localizes female receptivity and locomotion
    phenotypes to distinguishable neuronal circuits, including a cholinergic requirement for receptivity
    (PMID:25291190). This supports a neuronal transcription-regulatory context for DATI, not a family-wide
    behavioral function. PR-domain-dependent histone methylation cannot be assigned to all zinc-finger
    members or to DATI merely from the broad family name.
  representative_members:
  - id: UniProtKB:Q9V4C9
    gene_symbol: dati
    organism: Drosophila melanogaster
    label: Datilografo, isoform B
    gene_review: genes/DROME/dati/dati-ai-review.yaml
references:
- id: file:projects/PROTNLM_EVALUATION/family-curation/evidence-c/PTHR16515.md
  title: PANTHER/InterPro and UniProt source extracts for PTHR16515
- id: file:interpro/panther/PTHR16515/PTHR16515-entries.csv
  title: PTHR16515 cached PANTHER member inventory
- id: PMID:25291190
  title: The KRÜPPEL-like transcription factor DATILÓGRAFO is required in specific cholinergic neurons
    for sexual receptivity in Drosophila females.
review_status: COMPLETE
reviewed_by: codex
review_date: '2026-09-10'
notes: Family and subfamily names are read from panther.obo; representative assignments are checked against
  the frozen UniProt PANTHER cross-references and available member inventory. Source provenance and sequence
  lengths are recorded in projects/PROTNLM_EVALUATION/family-curation/evidence-c/PTHR16515.md. Functional
  statements derived from ARBA and LLM-generated descriptions are not independent validation. No PAINT
  ancestral-node placement or residue-loss assertion is made without the corresponding phylogenetic or
  sequence analysis.