family_id: PANTHER:PTHR21255
family_name: T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN
preferred_name: Tctex-type dynein light chains
summary: Tctex-type proteins are small noncatalytic dynein-associated subunits with distinct roles in
  cytoplasmic and ciliary transport assemblies. DYNLT2B/TCTEX1D2 is an accessory component of dynein-2
  required for efficient retrograde intraflagellar transport. ATP-driven motility belongs to the dynein
  motor machinery rather than the light chain itself.
functional_coherence: HETEROGENEOUS
coherence_reason: The member inventory contains several Tctex paralogs, and direct TCTEX1D2 experiments
  define its dynein-2 specialization. Rhodopsin-binding observations for Tctex-1 cannot be used to assign
  that cargo or a photoreceptor-specific role to DYNLT2B or every family member.
reference_protein:
  id: UniProtKB:Q8WW35
  gene_symbol: DYNLT2B
  organism: Homo sapiens
  label: Dynein light chain Tctex-type protein 2B
  gene_review: genes/human/DYNLT2B/DYNLT2B-ai-review.yaml
subfamilies:
- subfamily_id: PANTHER:PTHR21255:SF7
  label: DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B
  description: The member inventory contains several Tctex paralogs, and direct TCTEX1D2 experiments define
    its dynein-2 specialization. Rhodopsin-binding observations for Tctex-1 cannot be used to assign that
    cargo or a photoreceptor-specific role to DYNLT2B or every family member.
  representative_members:
  - id: UniProtKB:A0A9L0SWY1
    gene_symbol: DYNLT2B
    organism: Equus caballus
    label: Dynein light chain Tctex-type 2B
    gene_review: genes/HORSE/DYNLT2B/DYNLT2B-ai-review.yaml
  - id: UniProtKB:Q8WW35
    gene_symbol: DYNLT2B
    organism: Homo sapiens
    label: Dynein light chain Tctex-type protein 2B
    gene_review: genes/human/DYNLT2B/DYNLT2B-ai-review.yaml
references:
- id: file:projects/PROTNLM_EVALUATION/family-curation/evidence-c/PTHR21255.md
  title: PANTHER/InterPro and UniProt source extracts for PTHR21255
- id: file:interpro/panther/PTHR21255/PTHR21255-entries.csv
  title: PTHR21255 cached PANTHER member inventory
- id: PMID:29742051
  title: Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is
    crucial for ciliary protein trafficking.
review_status: COMPLETE
reviewed_by: codex
review_date: '2026-09-10'
notes: Family and subfamily names are read from panther.obo; representative assignments are checked against
  the frozen UniProt PANTHER cross-references and available member inventory. Source provenance and sequence
  lengths are recorded in projects/PROTNLM_EVALUATION/family-curation/evidence-c/PTHR21255.md. Functional
  statements derived from ARBA and LLM-generated descriptions are not independent validation. No PAINT
  ancestral-node placement or residue-loss assertion is made without the corresponding phylogenetic or
  sequence analysis.