family_id: PANTHER:PTHR38710
family_name: WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED
preferred_name: Plant glucuronokinases
summary: Glucuronokinases use ATP to phosphorylate glucuronic acid in a route for recycling uronic acids
  into nucleotide-sugar metabolism. They have GHMP-kinase architecture rather than the reaction implied
  by a uridyl-pyrophosphorylase name.
functional_coherence: COHERENT
coherence_reason: The wheat target has both GHMP-kinase regions and glucuronokinase-family placement.
  Biochemical ATP-dependent phosphate donation supports phosphorylation as a conserved reaction class;
  a complete substrate-specific assignment should retain the glucuronic-acid context.
subfamilies:
- subfamily_id: PANTHER:PTHR38710:SF1
  label: WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED
  description: Recorded placement of A0A3B6NKR6. The wheat target has both GHMP-kinase regions and glucuronokinase-family
    placement. Biochemical ATP-dependent phosphate donation supports phosphorylation as a conserved reaction
    class; a complete substrate-specific assignment should retain the glucuronic-acid context.
  representative_members:
  - id: UniProtKB:A0A3B6NKR6
    gene_symbol: A0A3B6NKR6
    organism: Triticum aestivum
    gene_review: genes/WHEAT/A0A3B6NKR6/A0A3B6NKR6-ai-review.yaml
term_assessments:
- assessed_term:
    id: GO:0016310
    label: phosphorylation
  scope: FAMILY_WIDE
  scope_reason: Purified lily enzyme and recombinant Arabidopsis glucuronokinase establish ATP-dependent
    phosphorylation of glucuronic acid. The wheat target retains both GHMP-kinase regions and the glucuronokinase-specific
    family signature, supporting the shared broad phosphorylation process for intact glucuronokinase-family
    members. This does not grant uridyl-pyrophosphorylase activity or establish a tissue-specific role.
  supported_by:
  - reference_id: PMID:19951951
    supporting_text: It requires ATP as phosphate donor
  - reference_id: file:genes/WHEAT/A0A3B6NKR6/A0A3B6NKR6-uniprot.txt
    supporting_text: DR   InterPro; IPR013750; GHMP_kinase_C_dom.
  - reference_id: file:genes/WHEAT/A0A3B6NKR6/A0A3B6NKR6-uniprot.txt
    supporting_text: DR   InterPro; IPR006204; GHMP_kinase_N_dom.
  - reference_id: file:genes/WHEAT/A0A3B6NKR6/A0A3B6NKR6-uniprot.txt
    supporting_text: DR   InterPro; IPR053034; Glucuronokinase-like.
  - reference_id: file:genes/WHEAT/A0A3B6NKR6/A0A3B6NKR6-uniprot.txt
    supporting_text: FT   DOMAIN          97..181
references:
- id: PMID:19951951
  title: Cloning of Glucuronokinase from Arabidopsis thaliana, the last missing enzyme of the myo-inositol
    oxygenase pathway to nucleotide sugars.
- id: file:genes/WHEAT/A0A3B6NKR6/A0A3B6NKR6-uniprot.txt
- id: file:interpro/panther/PTHR38710/PTHR38710-entries.csv
- id: file:interpro/panther/PTHR38710/PTHR38710-paint.tsv
review_status: COMPLETE
reviewed_by: codex
review_date: '2026-09-10'
notes: 'WHEAT/A0A3B6NKR6: requested accession A0A3B6NKR6; current record A0A3B6NKR6; sequence length 360;
  source cohort ARGO50. Family boundaries were assessed using the fetched member set and the cited domain,
  literature and analytical evidence. Gene-review verdicts and ARBA assertions are not independent validation.
  PANTHER subfamily labels and membership are recorded from the frozen UniProt records and panther.obo;
  they do not by themselves prove functional uniformity within a subfamily. PAINT rows were inspected
  as ancestral assertions, but node placement is not adjudicated without the relevant descendant tree/alignment.
  No residue requirement is encoded without a verified sequence-version anchor. A target-level refutation
  is not a family-wide NOT_APPLICABLE judgment. Exact protein-name-only predictions are treated as family-identification
  hypotheses rather than invented GO predictions.'