family_id: PANTHER:PTHR47219
family_name: RAB GTPASE-ACTIVATING PROTEIN 1-LIKE
preferred_name: TBC-domain trafficking regulators
summary: TBC-domain proteins include Rab GTPase-activating enzymes and noncatalytic trafficking regulators.
  Rab preference, organelle recruitment and catalytic competence vary among branches.
functional_coherence: HETEROGENEOUS
coherence_reason: TBC1D14 regulates autophagosome formation from a recycling-endosome/Golgi context and
  is not a Rab11 GAP in the cited assays. The cod member is assigned TBC1D12-like, so both paralog identity
  and actual autophagosome residence remain unresolved. Neither the TBC fold nor an autophagy phenotype
  establishes the proposed compartment.
subfamilies:
- subfamily_id: PANTHER:PTHR47219:SF15
  label: TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1
  description: Recorded placement of A0A8C5FPT8. TBC1D14 binds Rab11 without acting as its GAP in the
    cited experiments. The cod target's frozen assignment is TBC1D12-like while its ProtNLM nearest-name
    lead is TBC1D14, so autophagosome transfer requires resolving this placement. Neither TBC-domain presence
    nor a Rab-GAP family label establishes autophagosome residence or GAP activity.
  representative_members:
  - id: UniProtKB:A0A8C5FPT8
    gene_symbol: A0A8C5FPT8
    organism: Gadus morhua
    gene_review: genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-ai-review.yaml
term_assessments:
- assessed_term:
    id: GO:0005776
    label: autophagosome
  scope: UNRESOLVED
  scope_reason: The TBC1D14 paper localizes the regulator to recycling endosomes and reports relocalization
    toward Golgi on starvation; regulation of autophagosome formation is not itself residence on an autophagosome.
    The cod target is assigned TBC1D12-like, whereas the prediction lead is TBC1D14. The location therefore
    requires both correct paralog placement and direct compartment evidence; the TBC fold and autophagy
    phenotype do not resolve it.
  supported_by:
  - reference_id: PMID:22613832
    supporting_text: "TBC1D14 binds activated Rab11 but is not a \nGAP for Rab11"
  - reference_id: file:genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-uniprot.txt
    supporting_text: DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
  - reference_id: file:genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-uniprot.txt
    supporting_text: FT   DOMAIN          388..596
  - reference_id: file:genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-uniprot.txt
    supporting_text: FT                   /note="Rab-GAP TBC"
  - reference_id: file:genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/protnlm.json
    supporting_text: "\"key\": \"phmmer_accession\",\n              \"value\": \"A6H7I8\""
  - reference_id: PMID:22613832
    supporting_text: "Amino acid starvation causes TBC1D14 to relocalize from REs to the \nGolgi complex"
references:
- id: PMID:22613832
  title: TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.
- id: file:genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/protnlm.json
- id: file:genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-uniprot.txt
- id: file:interpro/panther/PTHR47219/PTHR47219-entries.csv
- id: file:interpro/panther/PTHR47219/PTHR47219-paint.tsv
review_status: COMPLETE
reviewed_by: codex
review_date: '2026-09-10'
notes: 'GADMO/A0A8C5FPT8: requested accession A0A8C5FPT8; current record A0A8C5FPT8; sequence length 709;
  source cohort ARGO50. Family boundaries were assessed using the fetched member set and the cited domain,
  literature and analytical evidence. Gene-review verdicts and ARBA assertions are not independent validation.
  PANTHER subfamily labels and membership are recorded from the frozen UniProt records and panther.obo;
  they do not by themselves prove functional uniformity within a subfamily. PAINT rows were inspected
  as ancestral assertions, but node placement is not adjudicated without the relevant descendant tree/alignment.
  No residue requirement is encoded without a verified sequence-version anchor. A target-level refutation
  is not a family-wide NOT_APPLICABLE judgment. Exact protein-name-only predictions are treated as family-identification
  hypotheses rather than invented GO predictions.'