family_id: PANTHER:PTHR47593
family_name: ZINC FINGER PROTEIN 4-LIKE
preferred_name: Plant ZFP7-related zinc-finger proteins
summary: These plant proteins contain C2H2-type zinc-finger domains. The retrieved characterized-member
  set is sparse, so specific transcriptional targets, signaling roles and localization boundaries remain
  incompletely resolved.
functional_coherence: UNKNOWN
coherence_reason: The soybean target has a C2H2 zinc finger, whereas the cited ABA and nuclear-localization
  experiment concerns ZFP3. ZFP3 evidence is a related-protein lead, not demonstration of all ZFP7-related
  proteins. Establish the target's relationship to the tested branch before transferring ABA inhibition.
subfamilies:
- subfamily_id: PANTHER:PTHR47593:SF9
  label: C2H2-TYPE DOMAIN-CONTAINING PROTEIN
  description: Recorded placement of C6T1A2. The soybean target has a C2H2 zinc finger, whereas the cited
    ABA and nuclear-localization experiment concerns ZFP3. ZFP3 evidence is a related-protein lead, not
    demonstration of all ZFP7-related proteins. Establish the target's relationship to the tested branch
    before transferring ABA inhibition.
  representative_members:
  - id: UniProtKB:C6T1A2
    gene_symbol: C6T1A2
    organism: Glycine max
    gene_review: genes/SOYBN/C6T1A2/C6T1A2-ai-review.yaml
term_assessments:
- assessed_term:
    id: GO:0009788
    label: negative regulation of abscisic acid-activated signaling pathway
  scope: UNRESOLVED
  scope_reason: The Arabidopsis ZFP3 study also tests related ZFP1, ZFP4, ZFP6 and ZFP7 overexpression,
    and the zfp3 zfp4 double mutant supports a negative ABA-response role. This is positive evidence for
    several related plant branches, not ZFP3 alone. Soybean transfer still requires paralog placement
    and preservation of that regulatory context; the complete active set is unresolved.
  supported_by:
  - reference_id: PMID:24808098
    supporting_text: ZFP3, a nuclear C2H2 zinc finger protein
  - reference_id: file:genes/SOYBN/C6T1A2/C6T1A2-uniprot.txt
    supporting_text: DR   InterPro; IPR053266; Zinc_finger_protein_7.
  - reference_id: file:genes/SOYBN/C6T1A2/C6T1A2-uniprot.txt
    supporting_text: DR   InterPro; IPR013087; Znf_C2H2_type.
  - reference_id: file:genes/SOYBN/C6T1A2/C6T1A2-uniprot.txt
    supporting_text: FT   DOMAIN          79..106
  - reference_id: file:genes/SOYBN/C6T1A2/C6T1A2-uniprot.txt
    supporting_text: FT                   /note="C2H2-type"
  - reference_id: PMID:24808098
    supporting_text: 'regulated overexpression of ZFP3 and the closely related

      ZFP1, ZFP4, ZFP6, and ZFP7 zinc finger factors confers ABA insensitivity to seed

      germination'
- assessed_term:
    id: GO:0005634
    label: nucleus
  scope: UNRESOLVED
  scope_reason: ZFP3 is explicitly reported as a nuclear C2H2 zinc-finger protein. The soybean protein
    has a compatible zinc-finger architecture, but nuclear localization is not established by the metal-binding
    fold alone or by every family member sharing it. Localization determinants and plant branch conservation
    bound the inference.
  supported_by:
  - reference_id: PMID:24808098
    supporting_text: ZFP3, a nuclear C2H2 zinc finger protein
  - reference_id: file:genes/SOYBN/C6T1A2/C6T1A2-uniprot.txt
    supporting_text: DR   InterPro; IPR053266; Zinc_finger_protein_7.
  - reference_id: file:genes/SOYBN/C6T1A2/C6T1A2-uniprot.txt
    supporting_text: DR   InterPro; IPR013087; Znf_C2H2_type.
  - reference_id: file:genes/SOYBN/C6T1A2/C6T1A2-uniprot.txt
    supporting_text: FT   DOMAIN          79..106
  - reference_id: file:genes/SOYBN/C6T1A2/C6T1A2-uniprot.txt
    supporting_text: FT                   /note="C2H2-type"
references:
- id: PMID:24808098
  title: The Arabidopsis ZINC FINGER PROTEIN3 Interferes with Abscisic Acid and Light Signaling in Seed
    Germination and Plant Development.
- id: file:genes/SOYBN/C6T1A2/C6T1A2-uniprot.txt
- id: file:interpro/panther/PTHR47593/PTHR47593-entries.csv
- id: file:interpro/panther/PTHR47593/PTHR47593-paint.tsv
review_status: COMPLETE
reviewed_by: codex
review_date: '2026-09-10'
notes: 'SOYBN/C6T1A2: requested accession C6T1A2; current record C6T1A2; sequence length 210; source cohort
  ARGO50. Family boundaries were assessed using the fetched member set and the cited domain, literature
  and analytical evidence. Gene-review verdicts and ARBA assertions are not independent validation. PANTHER
  subfamily labels and membership are recorded from the frozen UniProt records and panther.obo; they do
  not by themselves prove functional uniformity within a subfamily. PAINT rows were inspected as ancestral
  assertions, but node placement is not adjudicated without the relevant descendant tree/alignment. No
  residue requirement is encoded without a verified sequence-version anchor. A target-level refutation
  is not a family-wide NOT_APPLICABLE judgment. Exact protein-name-only predictions are treated as family-identification
  hypotheses rather than invented GO predictions.'