# Curated Pfam entry review (entry-centric; see src/ai_gene_review/schema/pfam_entry_review.yaml).
# Sidecar to the machine-fetched PF16552-metadata.yaml (do not hand-edit metadata).
# Hand-curated; examples/counter-examples verified against UniProt (reviewed entries).
pfam_id: PF16552
pfam_name: OAM_alpha
pfam_description: Alpha subunit of D-ornithine 4,5-aminomutase (adenosylcobalamin-dependent).
interpro:
  id: InterPro:IPR015130
  label: Lys-AminoMut_A
  type: Domain
  member_pfams:
  - id: Pfam:PF16552
    label: OAM_alpha
    is_subject: true
    note: D-ornithine 4,5-aminomutase alpha subunit
  - id: Pfam:PF09043
    label: Lys-AminoMut_A
    note: D-lysine 5,6-aminomutase alpha subunit (a distinct aminomutase)
  go_status: ABSENT
  mapping_viability: NOT_VIABLE
  viability_reason: >-
    Same heterogeneous entry as PF09043: it groups D-ornithine 4,5-aminomutase with
    D-lysine 5,6-aminomutase, so the specific activity fits only the individual Pfam.
proposed_annotations:
- term:
    id: GO:0047831
    label: D-ornithine 4,5-aminomutase activity
  relation:
    id: RO:0002327
    label: enables
  aspect: molecular_function
  confidence: MEDIUM
  status: PROPOSED
  rationale: >-
    The reviewed member is the alpha subunit of D-ornithine 4,5-aminomutase (OAM-S;
    EC 5.4.3.5). MEDIUM because the family is small/specialized and shares the cobalamin
    mutase architecture with its sibling (D-lysine 5,6-aminomutase).
  supporting_examples:
  - accession: UniProt:E3PY96
    protein_name: OAMS_ACESD (D-ornithine 4,5-aminomutase subunit alpha)
    organism: Acetoanaerobium sticklandii
    ec: 5.4.3.5
    reviewed: true
  counter_examples:
  - accession: UniProt:E3PRJ5
    protein_name: KAMD_ACESD (lysine 5,6-aminomutase alpha subunit)
    organism: Acetoanaerobium sticklandii
    member_pfam: Pfam:PF09043
    ec: 5.4.3.3
    reviewed: true
    reason: Sibling family with a different aminomutase activity (D-lysine 5,6); an entry-level D-ornithine term would mis-annotate it.
notes: >-
  Mirror of the PF09043 review; the two specialized aminomutases supply each other's
  counter-example under the shared IPR015130 domain.