Agent-Based Model Derived from module 7 elements · 6 transitions

Agent-based model of pH-dependent FcRn (FCGRT/B2M) IgG and albumin salvage, exocytic recycling, and lysosomal catabolism

Simulates 100 discrete IgG/albumin cargo agents traversing the seven stages of endothelial and epithelial FcRn trafficking under uniform uncalibrated default transition rates (base_rate = 0.45, competing_inhibitor_factor = 0.25). Under wild-type baseline conditions, active FcRn acidic capture (fcrn_ph_dependent_salvage) attenuates late-endosomal routing (rab7_late_endosome_routing) from acidified sorting endosomes, rescuing 80% of internalized IgG/albumin via EHD1/SNAP23 exocytic recycling (ehd1_snap23_salvage_exocytosis) while only 20% undergoes lysosomal catabolism (ctsd_lysosomal_catabolism). Inactivating FcRn salvage (modeling FCGRT/B2M deficiency or therapeutic anti-FcRn blockade such as efgartigimod) diverts 100% of internalized cargo into RAB7A/CTSD lysosomal catabolism.

Module: Neonatal Fc receptor (FCGRT/B2M) pH-dependent IgG and albumin salvage and transcytosis — endocytic uptake, V-ATPase acidification, FcRn acidic capture, EHD1/SNAP23 exocytic recycling vs. RAB7A/CTSD lysosomal catabolism Source YAML: modules/fcrn_igg_albumin_salvage_transcytosis.yaml

Compartment Trafficking & Discrete Cargo Routing

t = 24 / 24

Cargo Occupancy Trajectory (t = 0 .. 24)

Derived Transition Rules & Effective Flux Rates

From Stage To Stage Predicate Modulators / Competing Branches Effective Rate