B cell receptor signaling pathway module

Antigen-bound B cell receptor complexes signal through CD79 ITAM subunits, SYK, BLNK, BTK, PLC-gamma, and PI3K to drive calcium, NF-kappaB, MAPK, and transcriptional responses.

MODULE:b_cell_receptor_signalingDRAFTSignaling Pathwaymodules/b_cell_receptor_signaling.yaml
B cell receptor signaling pathwayGO:0050853
file:modules/b_cell_receptor_signaling-deep-research-falcon.md
B cell receptor signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0050853
B cell receptor signaling pathway
The module is grounded in the GO biological process term for B cell receptor signaling pathway.
PANTHER:PTN000005673
PAINT node PTN000005673 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005737, C:GO:0016020, F:GO:0052742, P:GO:0046854; PAINT date 20260528.
PANTHER:PTN000005674
PAINT node PTN000005674 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005886, F:GO:0016303, F:GO:0035005, P:GO:0043491; PAINT date 20240205.
PANTHER:PTN000371571
PAINT node PTN000371571 for CD79A
Local PAINT IBD node in PTHR14334 with propagated terms C:GO:0019815; PAINT date 20241120.
PANTHER:PTN000700360
PAINT node PTN000700360 for BTK
Local PAINT IBD node in PTHR24418 with propagated terms P:GO:0050853; PAINT date 20221008.
PANTHER:PTN000799655
PAINT node PTN000799655 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005942; PAINT date 20240516.
PANTHER:PTN000799659
PAINT node PTN000799659 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005943, C:GO:0005944, F:GO:0046934; PAINT date 20240918.
PANTHER:PTN001019935
PAINT node PTN001019935 for BLNK
Local PAINT IBD node in PTHR14098 with propagated terms C:GO:0005737, F:GO:0030674, P:GO:0035556; PAINT date 20250821.
PANTHER:PTN001019940
PAINT node PTN001019940 for BLNK
Local PAINT IBD node in PTHR14098 with propagated terms F:GO:0035591, P:GO:0050853; PAINT date 20250821.
PANTHER:PTN001231474
PAINT node PTN001231474 for BTK
Local PAINT IBD node in PTHR24418 with propagated terms F:GO:0004715; PAINT date 20221008.
PANTHER:PTN002521457
PAINT node PTN002521457 for SYK
Local PAINT IBD node in PTHR24418 with propagated terms C:GO:0005886, F:GO:0004713; PAINT date 20260529.
PANTHER:PTN002815343
PAINT node PTN002815343 for SYK
Local PAINT IBD node in PTHR24418 with propagated terms P:GO:0050853; PAINT date 20210531.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
7Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • b_cell_receptor_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (1/7 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 6 missing review · 1 reviewed but lacking deep research

Gene Review Complete Deep research
CD79A P11912 ✗ — —
CD79B P40259 ✗ — —
SYK P43405 ✗ — —
PIK3CG P48736 ✗ — —
PLCG2 P16885 ✓ 166/167 ✗
BTK Q06187 ✗ — —
BLNK Q8WV28 ✗ — —

Details

Context
jawed vertebratesNCBITaxon:7776
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
B cell receptor signaling pathwaySignaling Pathwayb_cell_receptor_signaling
B cell receptor signaling pathwayGO:0050853
Context
jawed vertebratesNCBITaxon:7776
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes bcr tyrosine kinase cascade.
SYK-BTK kinase cascade leads to bcr second-messenger output.
Part 1: bcr antigen receptor engagement
BCR antigen receptor engagementRegulatory Stepbcr_antigen_receptor_engagement

CD79A and CD79B provide signaling ITAM subunits for the B cell antigen receptor.

Annotons

CD79A signaling subunit
cd79a_cd79a_signaling_subunit
Participant: Family: CD79A signaling subunit family/ortholog group
Family:
CD79A signaling subunit family/ortholog groupPANTHER:PTHR14334
Representative Members: CD79AUniProtKB:P11912

Curated exemplar for the cd79a signaling subunit role in B cell receptor signaling pathway.

CD79B signaling subunit
cd79b_cd79b_signaling_subunit
Participant: Family: CD79B signaling subunit family/ortholog group
Family:
CD79B signaling subunit family/ortholog groupPANTHER:PTHR14334
Representative Members: CD79BUniProtKB:P40259

Curated exemplar for the cd79b signaling subunit role in B cell receptor signaling pathway.

Part 2: bcr tyrosine kinase cascade
SYK-BTK kinase cascadeRegulatory Stepsyk_btk_kinase_cascade

SYK initiates and BTK amplifies phosphotyrosine signaling downstream of BCR engagement.

Annotons

SYK tyrosine kinase
syk_syk_tyrosine_kinase
Participant: Family: SYK tyrosine kinase family/ortholog group
Family:
SYK tyrosine kinase family/ortholog groupPANTHER:PTHR24418
Representative Members: SYKUniProtKB:P43405

Curated exemplar for the syk tyrosine kinase role in B cell receptor signaling pathway.

BTK tyrosine kinase
btk_btk_tyrosine_kinase
Participant: Family: BTK tyrosine kinase family/ortholog group
Family:
BTK tyrosine kinase family/ortholog groupPANTHER:PTHR24418
Representative Members: BTKUniProtKB:Q06187

Curated exemplar for the btk tyrosine kinase role in B cell receptor signaling pathway.

BLNK scaffold adaptor
blnk_blnk_scaffold_adaptor
Participant: Family: BLNK scaffold adaptor family/ortholog group
Family:
BLNK scaffold adaptor family/ortholog groupPANTHER:PTHR14098
Representative Members: BLNKUniProtKB:Q8WV28

Curated exemplar for the blnk scaffold adaptor role in B cell receptor signaling pathway.

Part 3: bcr second-messenger output
BCR second-messenger outputRegulatory Stepbcr_second_messenger_output

PLC-gamma and PI3K branches generate calcium and lipid signals for transcriptional activation.

Annotons

PLCG2 effector
plcg2_plcg2_effector
Participant: Gene Product: PLCG2
Gene Product:
PLCG2UniProtKB:P16885

Curated exemplar for the plcg2 effector role in B cell receptor signaling pathway.

PI3K catalytic branch
pik3cg_pi3k_catalytic_branch
Participant: Family: PI3K catalytic branch family/ortholog group
Family:
PI3K catalytic branch family/ortholog groupPANTHER:PTHR10048
Representative Members: PIK3CGUniProtKB:P48736

Curated exemplar for the pi3k catalytic branch role in B cell receptor signaling pathway.