Reusable Pseudomonas module linking methyl-accepting chemoreceptor input and adaptation through CheW-coupled CheA/CheY phosphotransfer, CheZ signal reset, C-ring switching, and proton-conducting flagellar stators. Pseudomonas putida proteins ground one realization without making receptor ligand specificity universal.
The module captures canonical signal flow rather than the complete PSEPK receptor repertoire. McpS and PcaY are receptor exemplars, not a claim of shared ligand specificity. KT2440 CheA carries a CheW-like coupling domain, but free CheW proteins still couple the receptor array to CheA. CheR2 and CheB1 represent receptor methylation and demethylation. Components from additional Pseudomonas chemotaxis systems are not assumed interchangeable. Flagellar construction is modeled separately.
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No MODULE:bacterial_chemotaxis_signal_transduction deep-research report alongside the module YAML.
1 leaf node(s) with no concrete protein grounding:
✓ every declared conforms_to bundle matches its template motif.
8 complete review(s) · 8 with deep research · 7 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| cheA Q88EW4 | ✓ | ✓ | ✓ |
| cheY Q88EW2 | ✓ | ✓ | ✓ |
| cheZ Q88EW3 | ✓ | ✓ | ✓ |
| fliG Q88ET5 | ✓ | ✓ | ✓ |
| mcpS Q88E10 | ✓ | ✓ | ✓ |
| motA Q88DC2 | ✓ | ✓ | ✓ |
| motB Q88DC3 | ✓ | ✓ | ✓ |
| pcaY Q88JK6 | ✓ | ✓ | ✓ |
| PSEPK CheR2 exemplar Q88ER1 | ✗ | — | — |
| PSEPK FliM exemplar Q88EU5 | ✗ | — | — |
| PSEPK FliN exemplar Q88EU6 | ✗ | — | — |
| PSEPK CheB1 exemplar Q88EW5 | ✗ | — | — |
| PSEPK MotC exemplar PP_4336 Q88EW6 | ✗ | — | — |
| PSEPK MotD exemplar PP_4335 Q88EW7 | ✗ | — | — |
| PSEPK CheW exemplar PP_4332 Q88EX0 | ✗ | — | — |
Ligand-dependent receptor states modulate CheA; attractants generally decrease CheA activity, whereas repellents or ligand-free states can increase it.
Detects chemoeffectors and controls the associated CheA signaling state.
Opposing receptor methylation and demethylation tune signaling sensitivity and permit adaptation to sustained stimuli.
Methylates receptor glutamate residues during sensory adaptation.
Demethylates adapted receptors and deamidates designated receptor glutamines.
Free CheW adaptors and the CheW-like P5 domain of CheA organize receptor-state input to CheA kinase activity.
Autophosphorylates and transfers phosphoryl groups to CheY and other response regulators.
Couples receptor arrays to CheA without catalyzing phosphotransfer.
Phosphorylated CheY binds the C-ring, principally through FliM, to alter rotation bias.
Accelerates CheY-P dephosphorylation to terminate and reset the switch signal.
Converts CheY-P binding at FliM into a change in C-ring conformation and rotation bias.
Conducts protons and supplies energy for torque generation by the assembled motor.
Provides an alternative proton-driven stator with a distinct contribution to KT2440 motility under semisolid conditions.
Stator proton conductance supplies torque while the C-ring switch sets rotational bias; neither is modeled as causally upstream of the other.