Bacterial chromosomal DNA replication

Reusable bacterial chromosome-replication module spanning origin initiation, fork unwinding and single-strand protection, RNA priming, DNA polymerase III synthesis and proofreading, sliding-clamp processivity, clamp loading, and Okazaki-fragment ligation. Verified Pseudomonas putida and Escherichia coli exemplars ground the conserved activities and complexes without restricting the module to either species.

The module models the conserved chromosome-replication mechanism rather than every protein in the broad KEGG map. DNA polymerase I gap filling, RNase H, repair exonucleases, and DNA ligase B are adjacent replication/repair activities outside the focused replisome realization. Molecular functions are attached only to leaf annotons. The loader's psi assignment at PP_0978 and the presence or absence of a theta subunit remain uncertain and are not asserted as exact exemplars. OpenScientist proposed PP_1552 as a DnaC helicase loader, but current UniProt and local metadata instead identify Q88ML9 as an unnamed phage replication protein; no exact DnaC, DnaI, or DciA exemplar is therefore asserted.