BMP signaling pathway module

BMP ligands activate type I and type II serine/threonine kinase receptor complexes that phosphorylate SMAD1/5-family effectors and regulate developmental patterning and differentiation.

MODULE:bmp_signalingDRAFTSignaling Pathwaymodules/bmp_signaling.yaml
BMP signaling pathwayGO:0030509
file:modules/bmp_signaling-deep-research-falcon.md
BMP signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0030509
BMP signaling pathway
The module is grounded in the GO biological process term for BMP signaling pathway.
PANTHER:PTN000218063
PAINT node PTN000218063 for BMP4
Local PAINT IBD node in PTHR11848 with propagated terms C:GO:0005576, F:GO:0005125, P:GO:0007178; PAINT date 20260528.
PANTHER:PTN002626129
PAINT node PTN002626129 for BMP4
Local PAINT IBD node in PTHR11848 with propagated terms P:GO:0008284; PAINT date 20250415.
PANTHER:PTN008330973
PAINT node PTN008330973 for BMP4
Local PAINT IBD node in PTHR11848 with propagated terms P:GO:0003007; PAINT date 20250403.
PANTHER:PTN008983382
PAINT node PTN008983382 for BMP4
Local PAINT IBD node in PTHR11848 with propagated terms P:GO:0030509; PAINT date 20250403.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
7Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • bmp_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (0/6 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 6 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
BMP4 P12644 ✗ — —
BMPR1A P36894 ✗ — —
SMAD4 Q13485 ✗ — —
BMPR2 Q13873 ✗ — —
SMAD1 Q15797 ✗ — —
SMAD5 Q99717 ✗ — —

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
BMP signaling pathwaySignaling Pathwaybmp_signaling
BMP signaling pathwayGO:0030509
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes receptor smad phosphorylation.
SMAD1/5 activation leads to bmp transcriptional output.
Part 1: bmp receptor engagement
BMP receptor engagementRegulatory Stepbmp_receptor_engagement

BMP4 ligand engages BMPR type I and type II receptor chains.

Annotons

BMP4 ligand
bmp4_bmp4_ligand
Participant: Family: BMP4 ligand family/ortholog group
Family:
BMP4 ligand family/ortholog groupPANTHER:PTHR11848
Representative Members: BMP4UniProtKB:P12644

Curated exemplar for the bmp4 ligand role in BMP signaling pathway.

BMPR1A type I receptor
bmpr1a_bmpr1a_type_i_receptor
Participant: Gene Product: BMPR1A
Gene Product:
BMPR1AUniProtKB:P36894

Curated exemplar for the bmpr1a type i receptor role in BMP signaling pathway.

BMPR2 type II receptor
bmpr2_bmpr2_type_ii_receptor
Participant: Gene Product: BMPR2
Gene Product:
BMPR2UniProtKB:Q13873

Curated exemplar for the bmpr2 type ii receptor role in BMP signaling pathway.

Part 2: receptor smad phosphorylation
SMAD1/5 activationRegulatory Stepsmad1_5_activation

BMP receptors phosphorylate receptor-regulated SMAD1 and SMAD5.

Annotons

SMAD1 receptor-regulated SMAD
smad1_smad1_receptor_regulated_smad
Participant: Gene Product: SMAD1
Gene Product:
SMAD1UniProtKB:Q15797

Curated exemplar for the smad1 receptor-regulated smad role in BMP signaling pathway.

SMAD5 receptor-regulated SMAD
smad5_smad5_receptor_regulated_smad
Participant: Gene Product: SMAD5
Gene Product:
SMAD5UniProtKB:Q99717

Curated exemplar for the smad5 receptor-regulated smad role in BMP signaling pathway.

Part 3: bmp transcriptional output
BMP transcriptional outputRegulatory Stepbmp_transcriptional_output

SMAD4 complexes relay BMP receptor activation to nuclear transcriptional responses.

Annotons

SMAD4 common mediator
smad4_smad4_common_mediator
Participant: Gene Product: SMAD4
Gene Product:
SMAD4UniProtKB:Q13485

Curated exemplar for the smad4 common mediator role in BMP signaling pathway.

SMAD1 transcriptional effector
smad1_smad1_transcriptional_effector
Participant: Gene Product: SMAD1
Gene Product:
SMAD1UniProtKB:Q15797

Curated exemplar for the smad1 transcriptional effector role in BMP signaling pathway.