AMP-activated protein kinase is a heterotrimeric energy sensor made of a catalytic alpha subunit, a scaffolding beta subunit with a glycogen-binding domain, and a gamma subunit whose CBS repeats bind AMP, ADP and ATP. Drosophila has a single gene for each subunit (AMPKalpha, alicorn and SNF4Agamma). When cellular energy falls, nucleotide binding to the gamma subunit promotes phosphorylation of the alpha activation loop by LKB1 and protects it from dephosphorylation. Active AMPK restores energy balance by inhibiting anabolic pathways, including TORC1 signaling and lipid synthesis, and promoting catabolism; in Drosophila it is also needed for epithelial polarity under energy stress and for normal lifespan and lipid storage.
Each subunit is encoded by a single Drosophila gene, so the complex has no subunit-isoform variants at the gene level. The upstream kinase Lkb1 is modelled in dmel_lkb1_strad_mo25_complex. FlyBase groups realized by this module: AMPK-C (FBgg0002066). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_ampk_complex.yaml. Member genes with a gene review in this repository: alc, AMPKalpha, SNF4Agamma.
All recommended fields populated.
✗ none found
No MODULE:dmel_ampk_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| dmel_ampk_complex_ampkalpha_ampkalpha | AMPKalpha UniProtKB:O18645 Gene |
AMP-activated protein kinase activity GO:0004679 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
0 complete review(s) · 3 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| alc A1Z7Q8 | ✓ | 10/11 | ✓ |
| AMPKalpha O18645 | ✓ | 42/43 | ✓ |
| SNF4Agamma Q9VDD2 | ✓ | 19/20 | ✓ |
Heterotrimeric energy-sensing kinase of AMPKalpha (catalytic), alicorn (beta) and SNF4Agamma (nucleotide-sensing gamma).
catalytic alpha subunit
nucleotide-sensing gamma subunit
beta scaffold subunit