Anaphase-promoting complex/cyclosome in Drosophila melanogaster

The anaphase-promoting complex/cyclosome (APC/C) is a large multisubunit RING E3 ubiquitin ligase that drives mitotic exit by targeting securin and mitotic cyclins for proteasomal degradation, and that keeps APC/C substrate levels low in G1. Its catalytic core is formed by the cullin-like subunit Apc2 (Morula) and the RING subunit Apc11 (Lemming A). A platform of Apc1 (Shattered), Apc4 and Apc5 (Ida) supports the core and an arc of tetratricopeptide-repeat subunits (Cdc27/Apc3, Cdc16/Apc6, Apc7 and Cdc23/Apc8). Substrates are recognized by Apc10 together with a WD40 coactivator, Fizzy (Cdc20) in mitosis or Fizzy-related (Cdh1) at mitotic exit and during endocycles.

MODULE:dmel_anaphase_promoting_complexDRAFTCONCRETEProtein Complexmodules/dmel_anaphase_promoting_complex.yaml
anaphase-promoting complexGO:0005680
FB:FBgg0000074
FlyBase gene group APC: Anaphase-promoting complex
FlyBase release FB2026_03 groups 12 D. melanogaster genes as anaphase-promoting complex (APC); this module models that group.
GO:0005680
anaphase-promoting complex
GO term grounding the module as anaphase-promoting complex.

FlyBase includes the coactivators Fzy and Fzr in the APC group; they are modelled as alternative coactivator variants. The meiosis-specific coactivator Cortex (cort) and Fizzy-related 2 are not FlyBase members of the group and are not modelled. Subunit-to-subcomplex placement follows the conserved APC/C architecture. FlyBase groups realized by this module: APC (FBgg0000074). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_anaphase_promoting_complex.yaml. None of the member genes has a gene review in this repository yet.

8Nodes
5Parts
1Variant Sets
2Variants
6Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_anaphase_promoting_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 2 evidence or coverage gap(s) (3 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
catalytic_core_complex PROTEIN_COMPLEX
Gene 		ubiquitin protein ligase activity
GO:0061630 		Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews.
apc_fzy_fzy fzy
UniProtKB:Q7KT59
Gene 		ubiquitin-protein transferase activator activity
GO:0097027 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
apc_fzr_fzr fzr
UniProtKB:Q9W4H9
Gene 		ubiquitin-protein transferase activator activity
GO:0097027 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.

Gene-review completeness (0/12 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 12 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
lmgA A8DYX7 ✗ — —
fzy Q7KT59 ✗ — —
Cdc23 Q9I7L8 ✗ — —
APC10 Q9V831 ✗ — —
Cdc16 Q9VCN6 ✗ — —
Cdc27 Q9VS37 ✗ — —
shtd Q9VXV3 ✗ — —
ida Q9VZL2 ✗ — —
mr Q9W1E5 ✗ — —
APC4 Q9W395 ✗ — —
APC7 Q9W3Y6 ✗ — —
fzr Q9W4H9 ✗ — —

Details

Context
Drosophila melanogasterNCBITaxon:7227
nucleusGO:0005634
Anaphase-promoting complexProtein Complexdmel_anaphase_promoting_complex

Multisubunit RING E3 ligase with Fizzy or Fizzy-related coactivators that ubiquitylates cyclins and securin for mitotic exit.

anaphase-promoting complexGO:0005680
Context
Drosophila melanogasterNCBITaxon:7227
nucleusGO:0005634
Part 1: cullin-RING catalytic core
Apc2-Apc11 catalytic coreProtein Complexcatalytic_core

Annotons

Apc2-Apc11 catalytic core
catalytic_core_complex
Participant: Protein Complex: Apc2-Apc11 catalytic core
Protein Complex:
Apc2-Apc11 catalytic core
Active units:
mr
Participant: Gene Product: mr
Gene Product:
mrUniProtKB:Q9W1E5
lmgA
Participant: Gene Product: lmgA
Gene Product:
lmgAUniProtKB:A8DYX7

Function

ubiquitin protein ligase activityGO:0061630
Part 2: scaffold platform
Apc1-Apc4-Apc5 platformProtein Complexplatform

Annotons

Apc1-Apc4-Apc5 platform
platform_complex
Participant: Protein Complex: Apc1-Apc4-Apc5 platform
Protein Complex:
Apc1-Apc4-Apc5 platform
Active units:
shtd
Participant: Gene Product: shtd
Gene Product:
shtdUniProtKB:Q9VXV3
APC4
Participant: Gene Product: APC4
Gene Product:
APC4UniProtKB:Q9W395
ida
Participant: Gene Product: ida
Gene Product:
idaUniProtKB:Q9VZL2
Part 3: tetratricopeptide-repeat arc
TPR subunitsProtein Complextpr_lobe

Annotons

TPR subunits
tpr_lobe_complex
Participant: Protein Complex: TPR subunits
Protein Complex:
TPR subunits
Active units:
Cdc27
Participant: Gene Product: Cdc27
Gene Product:
Cdc27UniProtKB:Q9VS37
Cdc16
Participant: Gene Product: Cdc16
Gene Product:
Cdc16UniProtKB:Q9VCN6
APC7
Participant: Gene Product: APC7
Gene Product:
APC7UniProtKB:Q9W3Y6
Cdc23
Participant: Gene Product: Cdc23
Gene Product:
Cdc23UniProtKB:Q9I7L8
Part 4: substrate recognition cofactor
Apc10Protein Complexapc10

Annotons

APC10 Apc10
apc10_apc10
Participant: Gene Product: APC10
Gene Product:
APC10UniProtKB:Q9V831
Part 5: substrate recruitment and activation
CoactivatorProtein Complexcoactivator
Variant set: Fizzy or Fizzy-related (Exactly One)
APC/C-Fizzy (Cdc20)Protein Complexapc_fzy

Annotons

fzy APC/C-Fizzy (Cdc20)
apc_fzy_fzy
Participant: Gene Product: fzy
Gene Product:
fzyUniProtKB:Q7KT59

Function

ubiquitin-protein transferase activator activityGO:0097027
APC/C-Fizzy-related (Cdh1)Protein Complexapc_fzr

Annotons

fzr APC/C-Fizzy-related (Cdh1)
apc_fzr_fzr
Participant: Gene Product: fzr
Gene Product:
fzrUniProtKB:Q9W4H9

Function

ubiquitin-protein transferase activator activityGO:0097027