Three conserved urea-cycle enzymes interconvert citrulline, arginine and ornithine in Drosophila. Argininosuccinate synthase (Ass) condenses citrulline with aspartate to form argininosuccinate, argininosuccinate lyase (Argl) cleaves it to arginine and fumarate, and arginase (Arg) hydrolyses arginine to ornithine and urea. Together the first two steps regenerate arginine from citrulline, and arginase links arginine to ornithine, the precursor of proline and polyamines. Insects are not known to run a complete urea cycle, so the three enzymes act as a branch of amino acid metabolism rather than as the main route of nitrogen excretion.
Boundary. The module covers the three FlyBase L-arginine metabolism enzymes. Arginine use by nitric oxide synthase (which yields citrulline) and by arginine kinase, and ornithine use for proline and polyamine synthesis, are connected pathways and not parts. The enzyme functions are assigned by orthology to the well-characterized urea-cycle enzymes. FlyBase groups realized by this module: ARGMET (FBgg0002186). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_arginine_metabolism.yaml. Member genes with a gene review in this repository: Arg, Argl, Ass.
All recommended fields populated.
✗ none found
No MODULE:dmel_arginine_metabolism deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
✓ every PRECEDES step chains, or its break is acknowledged via chaining_status.
3 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (3 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| argininosuccinate_synthesis_ass | Ass UniProtKB:O97069 Gene |
argininosuccinate synthase activity GO:0004055 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| argininosuccinate_cleavage_argl | Argl UniProtKB:Q9VLG9 Gene |
argininosuccinate lyase activity GO:0004056 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| arginine_hydrolysis_arg | Arg UniProtKB:O76895 Gene |
arginase activity GO:0004053 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
2 complete review(s) · 3 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Arg O76895 | ✓ | 11/13 | ✓ |
| Argl Q9VLG9 | ✓ | ✓ | ✓ |
| Ass O97069 | ✓ | ✓ | ✓ |
Ass and Argl regenerate arginine from citrulline, and arginase converts arginine to ornithine and urea.