ATR-ATRIP checkpoint kinase complex in Drosophila melanogaster

ATR is a phosphatidylinositol 3-kinase-related protein kinase that responds to single-stranded DNA at stalled replication forks and processed DNA breaks. Its partner ATRIP binds RPA-coated single-stranded DNA and recruits ATR, which then phosphorylates checkpoint targets such as Chk1 to arrest the cell cycle and stabilize replication forks. In Drosophila ATR is encoded by mei-41 and ATRIP by mus304; mutants are sensitive to DNA damage and are defective in DNA damage checkpoints.

MODULE:dmel_atr_atrip_complexDRAFTCONCRETEProtein Complexmodules/dmel_atr_atrip_complex.yaml
ATR-ATRIP complexGO:0070310
FB:FBgg0002117
FlyBase gene group ATR-ATRIP: Atr-atrip dna damage-sensing kinase complex
FlyBase release FB2026_03 groups 2 D. melanogaster genes as atr-atrip dna damage-sensing kinase complex (ATR-ATRIP); this module models that group.
GO:0070310
ATR-ATRIP complex
GO term grounding the module as ATR-ATRIP complex.

Upstream activators (9-1-1 clamp, TopBP1) and downstream effectors (Chk1, encoded by grp) are outside the module; see dmel_9_1_1_checkpoint_clamp. FlyBase groups realized by this module: ATR-ATRIP (FBgg0002117). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_atr_atrip_complex.yaml. Member genes with a gene review in this repository: mei-41, mus304.

3Nodes
2Parts
0Variant Sets
0Variants
2Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_atr_atrip_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
dmel_atr_atrip_complex_mei_41_mei_41 mei-41
UniProtKB:Q9VXG8
Gene 		protein serine/threonine kinase activity
GO:0004674 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (2/2 grounded genes reviewed)

1 complete review(s) · 2 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
mei-41 Q9VXG8 ✓ 39/40 ✓
mus304 Q9VVN4 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
nucleusGO:0005634
ATR-ATRIP complexProtein Complexdmel_atr_atrip_complex

ATR (Mei-41) checkpoint kinase with its ssDNA-recruitment partner ATRIP (Mus304).

ATR-ATRIP complexGO:0070310
Context
Drosophila melanogasterNCBITaxon:7227
nucleusGO:0005634
Part 1: ATR catalytic kinase subunit
mei-41Moduledmel_atr_atrip_complex_mei_41

Annotons

mei-41 subunit
dmel_atr_atrip_complex_mei_41_mei_41
Participant: Gene Product: mei-41
Gene Product:
mei-41UniProtKB:Q9VXG8

Function

protein serine/threonine kinase activityGO:0004674

ATR catalytic kinase subunit

Part 2: ATRIP recruitment subunit
mus304Moduledmel_atr_atrip_complex_mus304

Annotons

mus304 subunit
dmel_atr_atrip_complex_mus304_mus304
Participant: Gene Product: mus304
Gene Product:
mus304UniProtKB:Q9VVN4

ATRIP recruitment subunit