Basement membranes are sheet-like extracellular matrices beneath epithelia and around muscles and organs. Their two self-assembling networks are made of laminin and type IV collagen. Drosophila has two laminin trimers, each made of one alpha chain (LanA or Wing blister) with the shared beta (LanB1) and gamma (LanB2) chains; laminins polymerise at the cell surface and initiate basement membrane assembly. Type IV collagen trimers of Col4a1 and Viking are made mainly by the fat body and hemocytes and then incorporated into basement membranes, where they form a cross-linked network that gives strength and shapes organs. Multiplexin (the collagen XV/XVIII homolog) and Pericardin (a collagen IV-like protein of the cardiac extracellular matrix) are additional collagens grouped with them.
Boundary. The module joins the FlyBase collagen and laminin groups. Other core basement membrane components, perlecan (trol), nidogen (Ndg) and SPARC, are not in these groups and are not added; the collagen IV cross-linking peroxidasin (Pxn) and the collagen-processing enzymes are also outside the module. The laminin alpha-chain composition is shown as two variants that share LanB1 and LanB2. Pericardin is grouped by FlyBase as a collagen and is found mainly in the cardiac and pericardial matrix rather than in all basement membranes. The connection from laminin to collagen IV summarises the assembly order shown for Drosophila embryos and is not a metabolic step. FlyBase groups realized by this module: COL (FBgg0001185), LMN (FBgg0001190). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_basement_membrane_network.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_basement_membrane_network deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
✓ every PRECEDES step chains, or its break is acknowledged via chaining_status.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 1 evidence or coverage gap(s) (4 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| laminin_lana_complex | PROTEIN_COMPLEX Gene |
extracellular matrix structural constituent GO:0005201 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
| laminin_wb_complex | PROTEIN_COMPLEX Gene |
extracellular matrix structural constituent GO:0005201 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
| collagen_iv_complex | PROTEIN_COMPLEX Gene |
extracellular matrix structural constituent conferring tensile strength GO:0030020 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
| other_collagens_prc | prc UniProtKB:Q9VTR6 Gene |
extracellular matrix structural constituent GO:0005201 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
0 complete review(s) · 0 with deep research · 8 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Mp M9ND55 | ✗ | — | — |
| Col4a1 P08120 | ✗ | — | — |
| LanB1 P11046 | ✗ | — | — |
| LanB2 P15215 | ✗ | — | — |
| LanA Q00174 | ✗ | — | — |
| wb Q8IP51 | ✗ | — | — |
| vkg Q9VMV5 | ✗ | — | — |
| prc Q9VTR6 | ✗ | — | — |
Laminin trimers and type IV collagen networks, with the collagens Multiplexin and Pericardin, that form Drosophila basement membranes.
collagen XV/XVIII homolog
collagen IV-like protein of the heart extracellular matrix