The biogenesis of lysosome-related organelles complexes BLOC-1, BLOC-2 and BLOC-3 are needed to form lysosome-related organelles such as melanosomes in mammals and pigment granules in Drosophila eyes. BLOC-1 is an eight-subunit complex of small coiled-coil proteins (including dysbindin, pallidin, muted and snapin) that cooperates with endosomal sorting to deliver cargo to these organelles. BLOC-2 contains the HPS3, HPS5 and HPS6 subunits in mammals; the Drosophila HPS5 homolog is pink (p). BLOC-3, a heterodimer of HPS1 and HPS4, is a guanine nucleotide exchange factor for Rab32 and Rab38 in mammals. BORC is a related complex that shares Blos1, Blos2 and Snapin with BLOC-1 and adds BORCS5, BORCS6, BORCS7, BORCS8 and KXD1 subunits; it recruits Arl8 to lysosomes and controls their positioning.
Decomposition. Each complex is one part. Blos1, Blos2 and Snapin are shared by BLOC-1 and BORC and appear in both parts. FlyBase places CG14562 in BLOC-2 without a clear mammalian ortholog name; it is kept as listed. The Rab32/Rab38 exchange activity of BLOC-3 is established in mammals and is not asserted here for Drosophila. No molecular function is assigned to any of the complexes: BLOC-1, BLOC-2 and BORC are adaptor and scaffold complexes with no established catalytic activity, and the BLOC-3 exchange activity is not asserted (see above). FlyBase groups realized by this module: BLOC (FBgg0000163), BORC (FBgg0001619). Subgroups folded into it: BLOC2, BLOC1, BLOC3. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_bloc_borc_complexes.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_bloc_borc_complexes deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
0 complete review(s) · 0 with deep research · 17 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Blos1 A1Z9S1 | ✗ | — | — |
| HPS1 A1Z9W1 | ✗ | — | — |
| HPS4 A1ZAX8 | ✗ | — | — |
| BORCS7 A1ZBV5 | ✗ | — | — |
| Blos3 A8JNV4 | ✗ | — | — |
| Muted Q0KI28 | ✗ | — | — |
| CG32590 Q8IR45 | ✗ | — | — |
| p Q9VHN9 | ✗ | — | — |
| CG14562 Q9VNX0 | ✗ | — | — |
| Snapin Q9VQF9 | ✗ | — | — |
| Blos4 Q9VTC2 | ✗ | — | — |
| Blos2 Q9VTE0 | ✗ | — | — |
| Pldn Q9VTM0 | ✗ | — | — |
| CG10681 Q9VTY4 | ✗ | — | — |
| Dysb Q9VVT5 | ✗ | — | — |
| BORCS5 Q9VYT1 | ✗ | — | — |
| BORCS6 Q9W0Q3 | ✗ | — | — |
BLOC-1, BLOC-2 and BLOC-3 for lysosome-related organelle biogenesis and the BLOC-1-related complex BORC for lysosome positioning.