Brahma (SWI/SNF) chromatin remodeling complexes in Drosophila melanogaster

Brahma complexes are the Drosophila SWI/SNF-family ATP-dependent chromatin remodelers. They use the Brahma (brm) ATPase to slide or evict nucleosomes, making DNA accessible to transcription factors, and act as trithorax group regulators that oppose Polycomb silencing. All forms share a core of brm, Moira, Bap55, Bap60, Brd7-9 and actin. The BAP form contains the ARID protein Osa, the PBAP form instead contains Polybromo, Bap170 and e(y)3, and a non-canonical form (ncBAP) contains Bicra. Different forms control different target genes in development.

MODULE:dmel_brahma_complexesDRAFTCONCRETEProtein Complexmodules/dmel_brahma_complexes.yaml
brahma complexGO:0035060
FB:FBgg0000294
FlyBase gene group BRM: Brahma complexes
FlyBase release FB2026_03 groups 15 D. melanogaster genes as brahma complexes (BRM); this module models that group.
GO:0035060
brahma complex
GO term grounding the module as brahma complex.

The three FlyBase subgroups are modelled as alternative complex forms, so shared core subunits (brm, mor, Bap55, Bap60, Brd7-9, actin) appear in each. PBAP is grounded to GO RSC-type complex (the PBAF-type branch) and ncBAP to GBAF complex by analogy with the mammalian GLTSCR1/BICRA-containing complex. FlyBase lists two actins (Act5C and Act42A) as BAP/PBAP members. FlyBase groups realized by this module: BRM (FBgg0000294). Subgroups folded into it: BAP, PBAP, NCBAP. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_brahma_complexes.yaml. None of the member genes has a gene review in this repository yet.

4Nodes
0Parts
1Variant Sets
3Variants
3Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_brahma_complexes deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 3 evidence or coverage gap(s) (3 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
bap_complex/brm brm
UniProtKB:P25439
Complex Unit 		ATP-dependent chromatin remodeler activity
GO:0140658 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
pbap_complex/brm brm
UniProtKB:P25439
Complex Unit 		ATP-dependent chromatin remodeler activity
GO:0140658 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
ncbap_complex/brm brm
UniProtKB:P25439
Complex Unit 		ATP-dependent chromatin remodeler activity
GO:0140658 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.

Gene-review completeness (0/15 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 15 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
mor A0A0B4JDA0 ✗ — —
d4 A0A0B4KEC3 ✗ — —
Bicra A0A0B4KI51 ✗ — —
Bap170 A1Z6M0 ✗ — —
Bap55 A1ZAS6 ✗ — —
Act42A P02572 ✗ — —
Act5C P10987 ✗ — —
brm P25439 ✗ — —
Snr1 Q24090 ✗ — —
osa Q8IN94 ✗ — —
polybromo Q9VC36 ✗ — —
Brd7-9 Q9VLX2 ✗ — —
e(y)3 Q9VWF2 ✗ — —
Bap60 Q9VYG2 ✗ — —
Bap111 Q9W384 ✗ — —

Details

Context
Drosophila melanogasterNCBITaxon:7227
chromatinGO:0000785
Brahma complexesProtein Complexdmel_brahma_complexes

SWI/SNF-family chromatin remodelers built around the Brahma ATPase, present as BAP, PBAP and non-canonical BAP forms.

brahma complexGO:0035060
Context
Drosophila melanogasterNCBITaxon:7227
chromatinGO:0000785
Variant set: Brahma complex forms (One Or More)
BAP complex (Osa-containing)Protein Complexbap

Annotons

BAP complex (Osa-containing)
bap_complex
Participant: Protein Complex: BAP complex (Osa-containing)
Protein Complex:
BAP complex (Osa-containing)GO:0035060
Active units:
Act42A
Participant: Gene Product: Act42A
Gene Product:
Act42AUniProtKB:P02572
Act5C
Participant: Gene Product: Act5C
Gene Product:
Act5CUniProtKB:P10987
Bap111
Participant: Gene Product: Bap111
Gene Product:
Bap111UniProtKB:Q9W384
Bap55
Participant: Gene Product: Bap55
Gene Product:
Bap55UniProtKB:A1ZAS6
Bap60
Participant: Gene Product: Bap60
Gene Product:
Bap60UniProtKB:Q9VYG2
Brd7-9
Participant: Gene Product: Brd7-9
Gene Product:
Brd7-9UniProtKB:Q9VLX2
Snr1
Participant: Gene Product: Snr1
Gene Product:
Snr1UniProtKB:Q24090
brm
Participant: Gene Product: brm
Gene Product:
brmUniProtKB:P25439
Function:
ATP-dependent chromatin remodeler activityGO:0140658
d4
Participant: Gene Product: d4
Gene Product:
d4UniProtKB:A0A0B4KEC3
mor
Participant: Gene Product: mor
Gene Product:
morUniProtKB:A0A0B4JDA0
osa
Participant: Gene Product: osa
Gene Product:
osaUniProtKB:Q8IN94
PBAP complex (Polybromo-containing)Protein Complexpbap

Annotons

PBAP complex (Polybromo-containing)
pbap_complex
Participant: Protein Complex: PBAP complex (Polybromo-containing)
Protein Complex:
PBAP complex (Polybromo-containing)GO:0016586
Active units:
Act42A
Participant: Gene Product: Act42A
Gene Product:
Act42AUniProtKB:P02572
Act5C
Participant: Gene Product: Act5C
Gene Product:
Act5CUniProtKB:P10987
Bap111
Participant: Gene Product: Bap111
Gene Product:
Bap111UniProtKB:Q9W384
Bap170
Participant: Gene Product: Bap170
Gene Product:
Bap170UniProtKB:A1Z6M0
Bap55
Participant: Gene Product: Bap55
Gene Product:
Bap55UniProtKB:A1ZAS6
Bap60
Participant: Gene Product: Bap60
Gene Product:
Bap60UniProtKB:Q9VYG2
Brd7-9
Participant: Gene Product: Brd7-9
Gene Product:
Brd7-9UniProtKB:Q9VLX2
Snr1
Participant: Gene Product: Snr1
Gene Product:
Snr1UniProtKB:Q24090
brm
Participant: Gene Product: brm
Gene Product:
brmUniProtKB:P25439
Function:
ATP-dependent chromatin remodeler activityGO:0140658
e(y)3
Participant: Gene Product: e(y)3
Gene Product:
e(y)3UniProtKB:Q9VWF2
mor
Participant: Gene Product: mor
Gene Product:
morUniProtKB:A0A0B4JDA0
polybromo
Participant: Gene Product: polybromo
Gene Product:
polybromoUniProtKB:Q9VC36
Non-canonical BAP complex (Bicra-containing)Protein Complexncbap

Annotons

Non-canonical BAP complex (Bicra-containing)
ncbap_complex
Participant: Protein Complex: Non-canonical BAP complex (Bicra-containing)
Protein Complex:
Non-canonical BAP complex (Bicra-containing)GO:0140288
Active units:
Act5C
Participant: Gene Product: Act5C
Gene Product:
Act5CUniProtKB:P10987
Bap55
Participant: Gene Product: Bap55
Gene Product:
Bap55UniProtKB:A1ZAS6
Bap60
Participant: Gene Product: Bap60
Gene Product:
Bap60UniProtKB:Q9VYG2
Bicra
Participant: Gene Product: Bicra
Gene Product:
BicraUniProtKB:A0A0B4KI51
Brd7-9
Participant: Gene Product: Brd7-9
Gene Product:
Brd7-9UniProtKB:Q9VLX2
brm
Participant: Gene Product: brm
Gene Product:
brmUniProtKB:P25439
Function:
ATP-dependent chromatin remodeler activityGO:0140658
mor
Participant: Gene Product: mor
Gene Product:
morUniProtKB:A0A0B4JDA0