Drosophila has two cGAS-like receptors, cGlr1 and cGlr2, that sense infection-associated nucleic acids and synthesize cyclic GMP-AMP dinucleotides. cGlr1 is activated by double-stranded RNA and produces 3',2'-cGAMP. The cyclic dinucleotides bind Sting, which signals through the IKK kinases to activate the NF-kappa-B family transcription factor Relish. Relish then induces Sting-regulated genes that restrict RNA virus infection.
Boundary. Core components only (FlyBase CGAS-STING-C). IKKbeta and Relish are shared with the Imd pathway. The role of IKKepsilon in Sting signaling is included because FlyBase lists it as core; no activity is asserted for it here. A generic cyclic GMP-AMP synthase activity is used for both cGLRs because the two enzymes differ in the cGAMP isomers they make. FlyBase groups realized by this module: CGAS-STING (FBgg0001792). Subgroups folded into it: CGAS-STING-C. FlyBase also curates regulator sets for this pathway, which are context and not modelled as parts: CGAS-STING-P (positive regulators of cgas-sting signaling pathway, 1 genes). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_cgas_sting_signaling.yaml. Member genes with a gene review in this repository: cGlr1, cGlr2, IKKbeta, IKKepsilon, Rel, Sting.
All recommended fields populated.
✗ none found
No MODULE:dmel_cgas_sting_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
3 gene-function check(s) reflected in core functions · 0 conflict(s) · 2 evidence or coverage gap(s) (5 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| cgas_like_receptors_cglr1 | cGlr1 UniProtKB:A1ZA55 Gene |
cyclic GMP-AMP synthase activity GO:0140699 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| cgas_like_receptors_cglr2 | cGlr2 UniProtKB:A8DYP7 Gene |
cyclic GMP-AMP synthase activity GO:0140699 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| sting_sting | Sting UniProtKB:A0A0B4LFY9 Gene |
cyclic GMP-AMP binding GO:0140702 |
Annotation Supported
A retained annotation or curated replacement supports this function, but core_functions does not yet reflect it. |
| ikk_kinases_ikkbeta | IKKbeta UniProtKB:Q9VEZ5 Gene |
IkappaB kinase activity GO:0008384 |
Annotation Supported
A retained annotation or curated replacement supports this function, but core_functions does not yet reflect it. |
| relish_rel | Rel UniProtKB:Q94527 Gene |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
5 complete review(s) · 6 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| cGlr1 A1ZA55 | ✓ | ✓ | ✓ |
| cGlr2 A8DYP7 | ✓ | ✓ | ✓ |
| IKKbeta Q9VEZ5 | ✓ | ✓ | ✓ |
| IKKepsilon Q9V3Y8 | ✓ | 34/36 | ✓ |
| Rel Q94527 | ✓ | ✓ | ✓ |
| Sting A0A0B4LFY9 | ✓ | ✓ | ✓ |
cGAS-like receptors make cyclic GMP-AMP that activates Sting, leading through IKK kinases to Relish-dependent antiviral gene expression.