Chromosomal passenger complexes in Drosophila melanogaster

The chromosomal passenger complex (CPC) moves from centromeres in early mitosis to the spindle midzone and midbody in anaphase and telophase. Its enzymatic subunit Aurora B kinase phosphorylates kinetochore substrates to correct erroneous microtubule attachments, supports the spindle assembly checkpoint and later promotes cytokinesis. INCENP binds and activates Aurora B and links it to the localization module, formed by Survivin (Deterin in Drosophila) and Borealin. In Drosophila male meiosis the Borealin paralog Australin replaces Borealin in a meiotic CPC.

MODULE:dmel_chromosomal_passenger_complexDRAFTCONCRETEProtein Complexmodules/dmel_chromosomal_passenger_complex.yaml
chromosome passenger complexGO:0032133
FB:FBgg0000127
FlyBase gene group CPC: Chromosomal passenger complexes
FlyBase release FB2026_03 groups 5 D. melanogaster genes as chromosomal passenger complexes (CPC); this module models that group.
GO:0032133
chromosome passenger complex
GO term grounding the module as chromosome passenger complex.

FlyBase subgroups CPC-MIT and CPC-MEI share aurB, Incenp and Det and differ only in Borealin (borr) or Australin (aust); the shared kinase module is modelled once and the localization module as variants. FlyBase groups realized by this module: CPC (FBgg0000127). Subgroups folded into it: CPC-MIT, CPC-MEI. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_chromosomal_passenger_complex.yaml. Member genes with a gene review in this repository: aurB, aust, borr, Det, Incenp.

5Nodes
2Parts
1Variant Sets
2Variants
3Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_chromosomal_passenger_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
kinase_module_complex/aurb aurB
UniProtKB:Q9VKN7
Complex Unit 		protein serine/threonine kinase activity
GO:0004674 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (5/5 grounded genes reviewed)

4 complete review(s) · 5 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
aurB Q9VKN7 ✓ 52/53 ✓
aust Q9VLD7 ✓ ✓ ✓
borr Q9VLD6 ✓ ✓ ✓
Det Q9VEM2 ✓ ✓ ✓
Incenp A0A0B4LFQ2 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
Chromosomal passenger complexProtein Complexdmel_chromosomal_passenger_complex

Aurora B-INCENP kinase module with a Deterin plus Borealin (mitotic) or Australin (meiotic) localization module.

chromosome passenger complexGO:0032133
Context
Drosophila melanogasterNCBITaxon:7227
Part 1: catalytic module
Aurora B-INCENP kinase moduleProtein Complexkinase_module

Annotons

Aurora B-INCENP kinase module
kinase_module_complex
Participant: Protein Complex: Aurora B-INCENP kinase module
Protein Complex:
Aurora B-INCENP kinase module
Active units:
aurB
Participant: Gene Product: aurB
Gene Product:
aurBUniProtKB:Q9VKN7
Function:
protein serine/threonine kinase activityGO:0004674
Incenp
Participant: Gene Product: Incenp
Gene Product:
IncenpUniProtKB:A0A0B4LFQ2
Part 2: centromere and midzone targeting
Survivin-Borealin localization moduleProtein Complexlocalization_module
Variant set: Mitotic or meiotic localization module (One Or More)
Deterin-Borealin (mitotic)Protein Complexmitotic_det_borr

Annotons

Deterin-Borealin (mitotic)
mitotic_det_borr_complex
Participant: Protein Complex: Deterin-Borealin (mitotic)
Protein Complex:
Deterin-Borealin (mitotic)
Active units:
Det
Participant: Gene Product: Det
Gene Product:
DetUniProtKB:Q9VEM2
borr
Participant: Gene Product: borr
Gene Product:
borrUniProtKB:Q9VLD6
Deterin-Australin (meiotic)Protein Complexmeiotic_det_aust

Annotons

Deterin-Australin (meiotic)
meiotic_det_aust_complex
Participant: Protein Complex: Deterin-Australin (meiotic)
Protein Complex:
Deterin-Australin (meiotic)
Active units:
Det
Participant: Gene Product: Det
Gene Product:
DetUniProtKB:Q9VEM2
aust
Participant: Gene Product: aust
Gene Product:
austUniProtKB:Q9VLD7