The transition zone is the region at the base of the cilium, just above the basal body, where Y-shaped links connect the axoneme to the ciliary membrane and form a diffusion barrier that controls which proteins enter the cilium. Its components include the MKS module, a membrane-associated complex of B9-domain proteins (B9d1, B9d2, Mks1), Cc2d2a and Tectonic, and Cep290, which links the barrier to the axoneme. In Drosophila, transition zone proteins act in the cilia of sensory neurons and in the long transition-zone-like region of spermatocyte cilia. Cep290, Chibby, Dilatory (Cep131) and Unc localize to the transition zone or basal body and are needed to assemble it and the cilium.
FlyBase groups TZ (all transition zone components), MKS and CEP290C overlap; the MKS and Cep290 complexes are modelled as parts, and TZ members outside them (Cby, dila, unc) as a third part. CG4975 is an Ataxin-10 homolog placed with Cep290 by FlyBase. An NPHP module comparable to the vertebrate NPHP1-NPHP4-RPGRIP1L complex is not represented in the FlyBase groups and is not modelled. No molecular function is assigned: the transition zone proteins are structural and gating components with no established molecular activity in Drosophila, and most have only ND molecular function annotations in GOA. FlyBase groups realized by this module: TZ (FBgg0000607), MKS (FBgg0000608), CEP290C (FBgg0000609). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_ciliary_transition_zone.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_ciliary_transition_zone deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
0 complete review(s) · 0 with deep research · 10 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| dila A1Z7Z9 | ✗ | — | — |
| Cc2d2a A1ZAV1 | ✗ | — | — |
| CG4975 B7YZJ4 | ✗ | — | — |
| Cby B9A0M5 | ✗ | — | — |
| B9d2 M9MRD5 | ✗ | — | — |
| B9d1 Q9VF59 | ✗ | — | — |
| tctn Q9VMH0 | ✗ | — | — |
| unc Q9VRF2 | ✗ | — | — |
| Mks1 Q9VYM3 | ✗ | — | — |
| Cep290 Q9W0M1 | ✗ | — | — |
MKS module, Cep290 complex and other transition zone proteins that build the ciliary gate at the base of the cilium.
Basal body and transition zone proteins required for transition zone assembly and ciliogenesis; they are not known to form one complex.