Conserved oligomeric Golgi (COG) complex in Drosophila melanogaster

The conserved oligomeric Golgi (COG) complex is an eight-subunit multisubunit tethering complex at the Golgi apparatus. It tethers COPI-derived vesicles that recycle Golgi resident proteins, such as glycosylation enzymes, between cisternae, and it interacts with Golgi SNAREs, Rab GTPases and COPI coat proteins. The complex is organized into two lobes, lobe A (Cog1-Cog4) and lobe B (Cog5-Cog8). In Drosophila, Cog5 is encoded by four way stop (fws), whose mutants are defective in male meiotic cytokinesis and Golgi organization during spermatogenesis.

Boundary. The module contains the eight COG subunits. Golgi SNAREs and Rabs that COG engages are partners, not parts. Lobe assignments follow the conserved organization established in yeast and mammals. No molecular function is assigned: COG is a multisubunit tethering complex for intra-Golgi retrograde vesicles, but the GO vesicle membrane tethering activity term is not annotated to the fly COG subunits, which mostly have ND molecular function annotations. FlyBase groups realized by this module: COG (FBgg0000467). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_cog_complex.yaml. None of the member genes has a gene review in this repository yet.