COMPASS-family histone H3K4 methyltransferase complexes in Drosophila melanogaster

Drosophila has three COMPASS-family complexes, each built around a different SET-domain histone H3 lysine 4 methyltransferase. Set1/COMPASS performs most bulk H3K4 di- and trimethylation, the Trithorax (Trx) complex maintains expression of Hox and other developmental genes against Polycomb silencing, and the Trithorax-related (Trr) complex monomethylates H3K4 at enhancers and carries the H3K27 demethylase Utx. All three share the WRAD core (Wds, Rbbp5, Ash2 and Dpy-30L1) that stimulates the methyltransferase. Trx is also found in TAC1, a complex with the CBP acetyltransferase Nejire and Sbf.

MODULE:dmel_compass_family_complexesDRAFTCONCRETEProtein Complexmodules/dmel_compass_family_complexes.yaml
histone methyltransferase complexGO:0035097
FB:FBgg0000313
FlyBase gene group COMP-C: Compass-type complexes
FlyBase release FB2026_03 groups 16 D. melanogaster genes as compass-type complexes (COMP-C); this module models that group.
FB:FBgg0000316
FlyBase gene group TAC1: Trithorax acetylation complex 1
FlyBase release FB2026_03 groups 3 D. melanogaster genes as trithorax acetylation complex 1 (TAC1); this module models that group.
GO:0035097
histone methyltransferase complex
GO term grounding the module as histone methyltransferase complex.

The FlyBase COMPASS-type subgroups are modelled as alternative complexes, so the shared WRAD subunits (wds, Rbbp5, ash2, Dpy-30L1) and Hcf appear in more than one. The Trx and Trr complexes are grounded to the GO terms for their mammalian counterparts (MLL1/2 and MLL3/4). TAC1 (a separate FlyBase group) is a distinct part because it shares Trx but not the WRAD core. FlyBase groups realized by this module: COMP-C (FBgg0000313), TAC1 (FBgg0000316). Subgroups folded into it: TRX-C, COMP, TRR. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_compass_family_complexes.yaml. None of the member genes has a gene review in this repository yet.

6Nodes
2Parts
1Variant Sets
3Variants
4Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_compass_family_complexes deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 5 evidence or coverage gap(s) (5 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
set1_compass_complex/set1 Set1
UniProtKB:Q5LJZ2
Complex Unit 		histone H3K4 methyltransferase activity
GO:0042800 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
trx_complex_complex/trx trx
UniProtKB:P20659
Complex Unit 		histone H3K4 methyltransferase activity
GO:0042800 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
trr_complex_complex/utx Utx
UniProtKB:Q9VL07
Complex Unit 		histone H3K27me2/H3K27me3 demethylase activity
GO:0071558 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
trr_complex_complex/trr trr
UniProtKB:Q8IRW8
Complex Unit 		histone H3K4 methyltransferase activity
GO:0042800 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
tac1_complex/nej nej
UniProtKB:M9MS40
Complex Unit 		histone acetyltransferase activity
GO:0004402 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.

Gene-review completeness (1/18 grounded genes reviewed)

1 complete review(s) · 1 with deep research · 17 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
Ncoa6 A8DYV5 ✗ — —
nej M9MS40 ✗ — —
trx P20659 ✗ — —
Set1 Q5LJZ2 ✗ — —
trr Q8IRW8 ✗ — —
ash2 Q94545 ✗ — —
wds Q9V3J8 ✗ — —
Hcf Q9V4C8 ✗ — —
Sbf Q9VGH9 ✗ — —
Dpy-30L1 Q9VKQ9 ✗ — —
Utx Q9VL07 ✗ — —
Mnn1 Q9VM47 ✗ — —
Rbbp5 Q9VPH8 ✗ — —
Ptip Q9VUB7 ✗ — —
Pa1 Q9VYZ8 ✗ — —
Lpt Q9W1H0 ✗ — —
Cfp1 Q9W352 ✗ — —
Wdr82 Q9VLN1 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
chromatinGO:0000785
COMPASS-family complexesProtein Complexdmel_compass_family_complexes

Set1/COMPASS, Trx and Trr histone H3K4 methyltransferase complexes sharing the WRAD core, plus the Trx-CBP TAC1 complex.

histone methyltransferase complexGO:0035097
Context
Drosophila melanogasterNCBITaxon:7227
chromatinGO:0000785
Part 1: H3K4 methyltransferase complexes
COMPASS-type H3K4 methyltransferase complexesProtein Complexcompass_h3k4_methyltransferase_complexes

Three alternative complexes, each with one SET-domain methyltransferase and the shared WRAD core.

Variant set: Set1, Trx or Trr complexes (One Or More)
Set1/COMPASS complexProtein Complexset1_compass

Annotons

Set1/COMPASS complex
set1_compass_complex
Participant: Protein Complex: Set1/COMPASS complex
Protein Complex:
Set1/COMPASS complexGO:0048188
Active units:
Cfp1
Participant: Gene Product: Cfp1
Gene Product:
Cfp1UniProtKB:Q9W352
Dpy-30L1
Participant: Gene Product: Dpy-30L1
Gene Product:
Dpy-30L1UniProtKB:Q9VKQ9
Hcf
Participant: Gene Product: Hcf
Gene Product:
HcfUniProtKB:Q9V4C8
Rbbp5
Participant: Gene Product: Rbbp5
Gene Product:
Rbbp5UniProtKB:Q9VPH8
Set1
Participant: Gene Product: Set1
Gene Product:
Set1UniProtKB:Q5LJZ2
Function:
histone H3K4 methyltransferase activityGO:0042800
Wdr82
Participant: Gene Product: Wdr82
Gene Product:
Wdr82UniProtKB:Q9VLN1
ash2
Participant: Gene Product: ash2
Gene Product:
ash2UniProtKB:Q94545
wds
Participant: Gene Product: wds
Gene Product:
wdsUniProtKB:Q9V3J8
Trx complexProtein Complextrx_complex

Annotons

Trx complex
trx_complex_complex
Participant: Protein Complex: Trx complex
Protein Complex:
Trx complexGO:0044665
Active units:
Dpy-30L1
Participant: Gene Product: Dpy-30L1
Gene Product:
Dpy-30L1UniProtKB:Q9VKQ9
Hcf
Participant: Gene Product: Hcf
Gene Product:
HcfUniProtKB:Q9V4C8
Mnn1
Participant: Gene Product: Mnn1
Gene Product:
Mnn1UniProtKB:Q9VM47
Rbbp5
Participant: Gene Product: Rbbp5
Gene Product:
Rbbp5UniProtKB:Q9VPH8
ash2
Participant: Gene Product: ash2
Gene Product:
ash2UniProtKB:Q94545
trx
Participant: Gene Product: trx
Gene Product:
trxUniProtKB:P20659
Function:
histone H3K4 methyltransferase activityGO:0042800
wds
Participant: Gene Product: wds
Gene Product:
wdsUniProtKB:Q9V3J8
Trr complexProtein Complextrr_complex

Annotons

Trr complex
trr_complex_complex
Participant: Protein Complex: Trr complex
Protein Complex:
Trr complexGO:0044666
Active units:
Dpy-30L1
Participant: Gene Product: Dpy-30L1
Gene Product:
Dpy-30L1UniProtKB:Q9VKQ9
Lpt
Participant: Gene Product: Lpt
Gene Product:
LptUniProtKB:Q9W1H0
Ncoa6
Participant: Gene Product: Ncoa6
Gene Product:
Ncoa6UniProtKB:A8DYV5
Pa1
Participant: Gene Product: Pa1
Gene Product:
Pa1UniProtKB:Q9VYZ8
Ptip
Participant: Gene Product: Ptip
Gene Product:
PtipUniProtKB:Q9VUB7
Rbbp5
Participant: Gene Product: Rbbp5
Gene Product:
Rbbp5UniProtKB:Q9VPH8
Utx
Participant: Gene Product: Utx
Gene Product:
UtxUniProtKB:Q9VL07
Function:
histone H3K27me2/H3K27me3 demethylase activityGO:0071558
ash2
Participant: Gene Product: ash2
Gene Product:
ash2UniProtKB:Q94545
trr
Participant: Gene Product: trr
Gene Product:
trrUniProtKB:Q8IRW8
Function:
histone H3K4 methyltransferase activityGO:0042800
wds
Participant: Gene Product: wds
Gene Product:
wdsUniProtKB:Q9V3J8
Part 2: Trx-CBP complex
Trithorax acetylation complex 1Protein Complextac1

Complex of Trithorax with the CBP histone acetyltransferase Nejire and the SET domain binding factor Sbf.

Annotons

Trithorax acetylation complex 1
tac1_complex
Participant: Protein Complex: Trithorax acetylation complex 1
Protein Complex:
Trithorax acetylation complex 1
Active units:
Sbf
Participant: Gene Product: Sbf
Gene Product:
SbfUniProtKB:Q9VGH9
nej
Participant: Gene Product: nej
Gene Product:
nejUniProtKB:M9MS40
Function:
histone acetyltransferase activityGO:0004402
trx
Participant: Gene Product: trx
Gene Product:
trxUniProtKB:P20659