Condensin I and condensin II in Drosophila melanogaster

Condensins are SMC complexes that compact and individualize chromosomes for segregation. Both condensin I and condensin II are built on a heterodimer of SMC2 and SMC4 (Gluon in Drosophila), whose ATPase heads are bridged by a kleisin subunit that recruits HEAT-repeat subunits. Condensin I contains the kleisin Barren (CAP-H) and the HEAT subunits Cap-D2 and Cap-G. Condensin II contains the kleisin Cap-H2 and the HEAT subunit Cap-D3; in Drosophila condensin II also promotes interphase chromosome territory formation and antagonizes homolog pairing.

The FlyBase subgroups COND-I and COND-II share SMC2 and glu, which are modelled once as the core part. FlyBase lists no CAP-G2 subunit for condensin II. The SMC subunits are given ATP hydrolysis activity (GO:0016887), which they carry in GOA (ISS, NAS, IEA); their ATPase heads, engaged across the heterodimer, drive the complex. GO has a complex-level term for SMC-complex DNA entrapment (GO:0061776 ATP-dependent topological DNA co-entrapment activity, used by PomBase for the fission yeast complexes), but it is not annotated to the Drosophila proteins and is not asserted here. FlyBase groups realized by this module: COND (FBgg0000167). Subgroups folded into it: COND-II, COND-I. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_condensin_complexes.yaml. None of the member genes has a gene review in this repository yet.