The COP9 signalosome (CSN) is an eight-subunit complex that removes the ubiquitin-like protein Nedd8 from cullins, thereby controlling the activity and assembly of cullin-RING ubiquitin ligases. Six subunits (CSN1, CSN2, CSN3, CSN4, CSN7 and CSN8) contain PCI domains and form a horseshoe-shaped scaffold, and two subunits (CSN5 and CSN6) contain MPN domains; CSN5 is the JAMM metalloprotease that carries the deneddylase activity. Drosophila has two CSN1 paralogs: CSN1b in the ubiquitous complex and CSN1a in a testis-specific variant. The Drosophila CSN2 subunit is encoded by alien.
FlyBase subgroups COP9 and COP9-T share seven subunits and differ only in CSN1b versus CSN1a; the shared subunits are modelled once. CSN1 is a PCI subunit but is modelled as its own part to hold the paralog variants. FlyBase groups realized by this module: COP9-C (FBgg0001828). Subgroups folded into it: COP9, COP9-T. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_cop9_signalosome.yaml. Member genes with a gene review in this repository: CSN5.
All recommended fields populated.
✗ none found
No MODULE:dmel_cop9_signalosome deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| mpn_catalytic_complex/csn5 | CSN5 UniProtKB:Q9XZ58 Complex Unit |
deNEDDylase activity GO:0019784 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
1 complete review(s) · 1 with deep research · 8 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| CSN5 Q9XZ58 | ✓ | ✓ | ✓ |
| CSN8 Q7KTH8 | ✗ | — | — |
| CSN3 Q8SYG2 | ✗ | — | — |
| alien Q94899 | ✗ | — | — |
| CSN4 Q9V345 | ✗ | — | — |
| CSN7 Q9V4S8 | ✗ | — | — |
| CSN6 Q9VCY3 | ✗ | — | — |
| CSN1a Q9VJR9 | ✗ | — | — |
| CSN1b Q9VVU5 | ✗ | — | — |
Eight-subunit cullin deneddylase complex with a CSN5 JAMM catalytic subunit and ubiquitous (CSN1b) or testis-specific (CSN1a) variants.