COPI coatomer in Drosophila melanogaster

Coatomer is the heptameric coat of COPI vesicles, which mediate retrograde transport from the Golgi apparatus to the endoplasmic reticulum and transport between Golgi cisternae. Coatomer is recruited en bloc to membranes by the small GTPase Arf1 in its GTP-bound form and binds cargo with dilysine and related sorting signals. Structurally it consists of a B-subcomplex (alpha, beta' and epsilon subunits) that forms the outer cage-like layer and an F-subcomplex (beta, gamma, delta and zeta subunits) that resembles the clathrin adaptor complexes and contacts the membrane.

Boundary. The module contains the seven coatomer subunits. The Arf1 GTPase (Arf79F in Drosophila), its GEFs and GAPs regulate coat recruitment and are context, not parts. No molecular function is assigned: coatomer is treated as a structural vesicle coat, and its subunits carry only structural molecule activity (IEA) in GOA. FlyBase groups realized by this module: COPI (FBgg0000087). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_copi_coat.yaml. None of the member genes has a gene review in this repository yet.