Core binding factors are heterodimeric transcription factors made of a Runt domain DNA-binding alpha subunit and a non-DNA-binding beta subunit that increases the alpha subunit's DNA-binding affinity. Drosophila has four Runt domain proteins, runt, lozenge (lz), RunxA and RunxB, and two beta subunits, Brother (Bro) and Big brother (Bgb). Runt acts as a pair-rule and sex determination gene and in neurogenesis, while lozenge specifies cell fates in the eye and crystal cells among hemocytes.
The alpha and beta subunits are emitted one annoton per gene because any of the Runt domain proteins can in principle pair with either beta subunit and the pairings used in each tissue are not fully defined. FlyBase groups realized by this module: CBF (FBgg0000769). Subgroups folded into it: RUNT, CBFB. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_core_binding_factor.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_core_binding_factor deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 4 evidence or coverage gap(s) (4 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| runt_domain_alpha_runxa | RunxA UniProtKB:M9PI08 Gene |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| runt_domain_alpha_runxb | RunxB UniProtKB:Q9VRA9 Gene |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| runt_domain_alpha_lz | lz UniProtKB:Q9W349 Gene |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| runt_domain_alpha_run | run UniProtKB:P22814 Gene |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
0 complete review(s) · 0 with deep research · 6 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| RunxA M9PI08 | ✗ | — | — |
| run P22814 | ✗ | — | — |
| Bro Q24039 | ✗ | — | — |
| Bgb Q24040 | ✗ | — | — |
| RunxB Q9VRA9 | ✗ | — | — |
| lz Q9W349 | ✗ | — | — |
Heterodimers of a Runt domain DNA-binding subunit with the Bro or Bgb beta subunit.