Cyclin K-Cdk12 complex in Drosophila melanogaster

Cdk12 and its partner cyclin K form a transcription-associated kinase that phosphorylates the C-terminal domain of elongating RNA polymerase II. CDK12 activity supports productive elongation and co-transcriptional processing, particularly of long genes. In Drosophila, Cdk12 has also been implicated in the control of transcription and chromatin silencing.

MODULE:dmel_cyclin_k_cdk12_complexDRAFTCONCRETEProtein Complexmodules/dmel_cyclin_k_cdk12_complex.yaml
cyclin K-CDK12 complexGO:0002944
FB:FBgg0002118
FlyBase gene group CLNK-C12: Cyclin k-cdk12 complex
FlyBase release FB2026_03 groups 2 D. melanogaster genes as cyclin k-cdk12 complex (CLNK-C12); this module models that group.
GO:0002944
cyclin K-CDK12 complex
GO term grounding the module as cyclin K-CDK12 complex.

Cyclin K also partners with Cdk13 in mammals; no Cdk13 complex is grouped by FlyBase. FlyBase groups realized by this module: CLNK-C12 (FBgg0002118). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_cyclin_k_cdk12_complex.yaml. Member genes with a gene review in this repository: Cdk12, CycK.

3Nodes
2Parts
0Variant Sets
0Variants
2Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_cyclin_k_cdk12_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

2 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (2 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
dmel_cyclin_k_cdk12_complex_cdk12_cdk12 Cdk12
UniProtKB:Q9VP22
Gene 		RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0008353 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
dmel_cyclin_k_cdk12_complex_cyck_cyck CycK
UniProtKB:Q961D1
Gene 		cyclin-dependent protein serine/threonine kinase regulator activity
GO:0016538 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (2/2 grounded genes reviewed)

2 complete review(s) · 2 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
Cdk12 Q9VP22 ✓ ✓ ✓
CycK Q961D1 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
nucleusGO:0005634
Cyclin K-Cdk12 complexProtein Complexdmel_cyclin_k_cdk12_complex

Cyclin K-Cdk12 kinase that phosphorylates the RNA polymerase II C-terminal domain during elongation.

cyclin K-CDK12 complexGO:0002944
Context
Drosophila melanogasterNCBITaxon:7227
nucleusGO:0005634
Part 1: catalytic kinase subunit
Cdk12Moduledmel_cyclin_k_cdk12_complex_cdk12

Annotons

Cdk12 subunit
dmel_cyclin_k_cdk12_complex_cdk12_cdk12
Participant: Gene Product: Cdk12
Gene Product:
Cdk12UniProtKB:Q9VP22

Function

RNA polymerase II CTD heptapeptide repeat kinase activityGO:0008353

catalytic kinase subunit

Part 2: cyclin regulatory subunit
CycKModuledmel_cyclin_k_cdk12_complex_cyck

Annotons

CycK subunit
dmel_cyclin_k_cdk12_complex_cyck_cyck
Participant: Gene Product: CycK
Gene Product:
CycKUniProtKB:Q961D1

Function

cyclin-dependent protein serine/threonine kinase regulator activityGO:0016538

cyclin regulatory subunit