Dg Dystroglycan
dystroglycan_dg
Participant: Gene Product: Dg
Gene Product:
Function
laminin receptor activityGO:0005055
Dystrophin glycoprotein complex in Drosophila melanogaster
The dystrophin glycoprotein complex (DGC) links the actin cytoskeleton to the extracellular matrix across the plasma membrane, mainly in muscle. Dystroglycan (Dg) spans the membrane: its extracellular part binds laminin and other matrix proteins and its cytoplasmic tail binds dystrophin, which in turn binds actin. Sarcoglycans form a transmembrane subcomplex that stabilizes the link, and the cytoplasmic adaptors dystrobrevin and syntrophins bind dystrophin and recruit signaling proteins. Drosophila has single dystrophin (Dys) and dystroglycan genes, one dystrobrevin, three sarcoglycans and two syntrophin-like genes. Loss of Dys or Dg causes age-dependent muscle degeneration, and Dg also acts in epithelial polarity and in the oocyte.
dystrophin-associated glycoprotein complexGO:0016010
FB:FBgg0000473
FlyBase gene group DGC: Dystrophin glycoprotein complex
FlyBase release FB2026_03 groups 8 D. melanogaster genes as dystrophin glycoprotein complex (DGC); this module models that group.
FB:FBgg0000479
FlyBase gene group SYN: Syntrophins
FlyBase release FB2026_03 groups 2 D. melanogaster genes as syntrophins (SYN); this module models that group.
FB:FBgg0000480
FlyBase gene group DYS-REL: Dystrophin-related proteins
FlyBase release FB2026_03 groups 2 D. melanogaster genes as dystrophin-related proteins (DYS-REL); this module models that group.
FB:FBgg0000481
FlyBase gene group SCG: Sarcoglycans
FlyBase release FB2026_03 groups 3 D. melanogaster genes as sarcoglycans (SCG); this module models that group.
GO:0016010
dystrophin-associated glycoprotein complex
GO term grounding the module as dystrophin-associated glycoprotein complex.
Extracellular ligands (laminins, perlecan) and dystroglycan glycosylation enzymes are context, not parts. Syntrophins and dystrophin/dystrobrevin are modelled per gene because their assembly into stable subcomplexes has not been shown in Drosophila. Dystroglycan is given laminin receptor activity (GO:0005055; GOA IDA, IBA). The other subunits carry structural or binding terms only (structural constituent of muscle by NAS, actin filament binding, WW domain binding) and are left without an annoton function. FlyBase groups realized by this module: DGC (FBgg0000473), SYN (FBgg0000479), DYS-REL (FBgg0000480), SCG (FBgg0000481). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_dystrophin_glycoprotein_complex.yaml. None of the member genes has a gene review in this repository yet.
5Nodes
4Parts
0Variant Sets
0Variants
6Annotons
1Connections
Derived QC
Recommended-field compliance
100.0%
recommended fields populated
All recommended fields populated.
Module deep research
✗ none found
No MODULE:dmel_dystrophin_glycoprotein_complex deep-research report alongside the module YAML.
Leaf nodes lacking representative members
✓ every leaf node grounds to a representative protein.
Template conformance
✓ every declared conforms_to bundle matches its template motif.
Function consistency and core coverage
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 1 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| dystroglycan_dg | Dg UniProtKB:A0A0C4DHF6 Gene |
laminin receptor activity GO:0005055 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
Gene-review completeness (0/8 grounded genes reviewed)
0 complete review(s) · 0 with deep research · 8 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Dg A0A0C4DHF6 | ✗ | — | — |
| Syn2 A1ZAH3 | ✗ | — | — |
| Dyb A8DYB7 | ✗ | — | — |
| Scgalpha M9PF78 | ✗ | — | — |
| Scgdelta O76892 | ✗ | — | — |
| Dys Q9VDW6 | ✗ | — | — |
| Scgbeta Q9VG77 | ✗ | — | — |
| Syn1 Q9VNY2 | ✗ | — | — |
Details
Context
Drosophila melanogasterNCBITaxon:7227
Dystrophin glycoprotein complexProtein Complexdmel_dystrophin_glycoprotein_complex
Dystroglycan, dystrophin, dystrobrevin, sarcoglycans and syntrophins linking actin to the extracellular matrix.
dystrophin-associated glycoprotein complexGO:0016010
Context
Drosophila melanogasterNCBITaxon:7227
Connections
The cytoplasmic tail of dystroglycan binds dystrophin, linking the matrix to actin.
Part 1: transmembrane matrix receptor
DystroglycanProtein Complexdystroglycan
Single Dg gene encoding the alpha and beta dystroglycan chains, which form the dystroglycan complex.
Annotons
Part 2: cytoplasmic actin linker and adaptor
Dystrophin and dystrobrevinProtein Complexdystrophin_and_dystrobrevin
Annotons
Dyb Dystrophin and dystrobrevin
dystrophin_and_dystrobrevin_dyb
Participant: Gene Product: Dyb
Gene Product:
Dys Dystrophin and dystrobrevin
dystrophin_and_dystrobrevin_dys
Participant: Gene Product: Dys
Gene Product:
Part 3: transmembrane stabilizing subcomplex
Sarcoglycan complexProtein Complexsarcoglycans
Annotons
Sarcoglycan complex
sarcoglycans_complex
Participant: Protein Complex: Sarcoglycan complex
Protein Complex:
Part 4: cytoplasmic adaptors
SyntrophinsProtein Complexsyntrophins
Annotons
Syn1 Syntrophins
syntrophins_syn1
Participant: Gene Product: Syn1
Gene Product:
Syn1UniProtKB:Q9VNY2
Syn2 Syntrophins
syntrophins_syn2
Participant: Gene Product: Syn2
Gene Product:
Syn2UniProtKB:A1ZAH3