The Drosophila eggshell is secreted by the somatic follicle cells that surround the oocyte during late oogenesis. The vitelline membrane, the innermost layer, is laid down first from vitelline membrane proteins (Vm26Aa, Vm26Ab, Vm26Ac, Vm32E, Vm34Ca and Vml) that are cross-linked into an insoluble layer. The chorion is secreted afterwards and is built from chorion proteins encoded mainly by two clusters: an X-linked cluster at 7F (Cp36, Cp38 and Cp7Fa-c) and an autosomal cluster at 66D (Cp15, Cp16, Cp18 and Cp19). The chorion gene clusters are amplified in follicle cells by developmentally regulated DNA re-replication, which allows the large and rapid synthesis of chorion proteins.
Each protein is a separate annoton (complex false): the eggshell layers are cross-linked extracellular structures, not defined stoichiometric complexes. Vitelline membrane proteins are assigned to the vitelline envelope GO component. Several eggshell components outside the two FlyBase groups (for example the dec-1 proteins, and peroxidases and other enzymes that cross-link the layers) are not modelled. The structural-constituent functions of most chorion and vitelline membrane proteins rest on their localization and curator inference rather than gene-by-gene mutant analysis. FlyBase groups realized by this module: VMP (FBgg0001184), CHORN (FBgg0001188). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_eggshell_structural_proteins.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_eggshell_structural_proteins deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
✓ every PRECEDES step chains, or its break is acknowledged via chaining_status.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 15 evidence or coverage gap(s) (15 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| vitelline_membrane_proteins_vm26aa | Vm26Aa UniProtKB:P11449 Gene |
structural constituent of vitelline membrane GO:0008316 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| vitelline_membrane_proteins_vm26ab | Vm26Ab UniProtKB:P13238 Gene |
structural constituent of vitelline membrane GO:0008316 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| vitelline_membrane_proteins_vm26ac | Vm26Ac UniProtKB:Q9VMK5 Gene |
structural constituent of vitelline membrane GO:0008316 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| vitelline_membrane_proteins_vm32e | Vm32E UniProtKB:Q9VKI3 Gene |
structural constituent of vitelline membrane GO:0008316 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| vitelline_membrane_proteins_vm34ca | Vm34Ca UniProtKB:Q06521 Gene |
structural constituent of vitelline membrane GO:0008316 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| vitelline_membrane_proteins_vml | Vml UniProtKB:A8JUV4 Gene |
structural constituent of vitelline membrane GO:0008316 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| chorion_cluster_7f_cp36 | Cp36 UniProtKB:P07182 Gene |
structural constituent of egg chorion GO:0005213 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| chorion_cluster_7f_cp38 | Cp38 UniProtKB:P07183 Gene |
structural constituent of egg chorion GO:0005213 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| chorion_cluster_7f_cp7fa | Cp7Fa UniProtKB:A0A6F7S5S7 Gene |
structural constituent of egg chorion GO:0005213 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| chorion_cluster_7f_cp7fb | Cp7Fb UniProtKB:Q9W3E8 Gene |
structural constituent of egg chorion GO:0005213 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| chorion_cluster_7f_cp7fc | Cp7Fc UniProtKB:Q9W3E7 Gene |
structural constituent of egg chorion GO:0005213 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| chorion_cluster_66d_cp15 | Cp15 UniProtKB:P07185 Gene |
structural constituent of egg chorion GO:0005213 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| chorion_cluster_66d_cp16 | Cp16 UniProtKB:P22977 Gene |
structural constituent of egg chorion GO:0005213 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| chorion_cluster_66d_cp18 | Cp18 UniProtKB:P07184 Gene |
structural constituent of egg chorion GO:0005213 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| chorion_cluster_66d_cp19 | Cp19 UniProtKB:P07186 Gene |
structural constituent of egg chorion GO:0005213 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
0 complete review(s) · 0 with deep research · 15 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Cp7Fa A0A6F7S5S7 | ✗ | — | — |
| Vml A8JUV4 | ✗ | — | — |
| Cp36 P07182 | ✗ | — | — |
| Cp38 P07183 | ✗ | — | — |
| Cp18 P07184 | ✗ | — | — |
| Cp15 P07185 | ✗ | — | — |
| Cp19 P07186 | ✗ | — | — |
| Vm26Aa P11449 | ✗ | — | — |
| Vm26Ab P13238 | ✗ | — | — |
| Cp16 P22977 | ✗ | — | — |
| Vm34Ca Q06521 | ✗ | — | — |
| Vm32E Q9VKI3 | ✗ | — | — |
| Vm26Ac Q9VMK5 | ✗ | — | — |
| Cp7Fc Q9W3E7 | ✗ | — | — |
| Cp7Fb Q9W3E8 | ✗ | — | — |
Follicle-cell secreted vitelline membrane and chorion proteins that build the two main layers of the eggshell.