Replication factor C (RFC) is a pentameric AAA+ clamp loader made of one large subunit and four small subunits. In the Elg1 RFC-like complex the large subunit Rfc1 is replaced by Elg1 (ATAD5 in mammals), while the four small RFC subunits are shared. In yeast and human cells this complex unloads the PCNA sliding clamp from DNA after Okazaki fragment ligation, and its loss raises genome instability.
The PCNA-unloading role is inferred from yeast and human Elg1/ATAD5; it has not been tested biochemically for the Drosophila complex. It is recorded as a complex-level DNA clamp unloader activity (GO:0061860), which Drosophila Elg1 carries in GOA by IBA, with all five AAA+ subunits as active units. FlyBase groups realized by this module: ELG1-C (FBgg0000599). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_elg1_rfc_like_complex.yaml. Member genes with a gene review in this repository: CG8142, elg1, RfC3, RfC38, RfC4.
All recommended fields populated.
✗ none found
No MODULE:dmel_elg1_rfc_like_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| dmel_elg1_rfc_like_complex_complex_activity | PROTEIN_COMPLEX Gene |
DNA clamp unloader activity GO:0061860 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
5 complete review(s) · 4 with deep research · 0 missing review · 1 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| CG8142 Q9VX15 | ✓ | ✓ | ✗ |
| elg1 Q86BP6 | ✓ | ✓ | ✓ |
| RfC3 Q9VKW3 | ✓ | ✓ | ✓ |
| RfC38 Q9U9Q1 | ✓ | ✓ | ✓ |
| RfC4 P53034 | ✓ | ✓ | ✓ |
RFC-like PCNA unloader in which Elg1 replaces the large Rfc1 subunit.
Unloads the PCNA sliding clamp from DNA after replication, by homology to yeast Elg1-RFC and human ATAD5-RFC.
The four small RFC subunits (Rfc2-5 homologs) shared with the canonical RFC clamp loader and the other RFC-like complexes.