Enok histone acetyltransferase complex in Drosophila melanogaster

Enok (Enoki mushroom) is the Drosophila MOZ/MORF (KAT6) family MYST histone acetyltransferase. It forms a complex with the bromodomain-PHD scaffold Br140 (BRPF homolog), the ING-family protein Ing5 and Eaf6, the same subunit composition as the mammalian MOZ/MORF complexes. Enok acetylates histone H3 and was first identified through its requirement for mushroom body neuroblast proliferation.

MODULE:dmel_enok_complexDRAFTCONCRETEProtein Complexmodules/dmel_enok_complex.yaml
MOZ/MORF histone acetyltransferase complexGO:0070776
FB:FBgg0000604
FlyBase gene group ENOK-C: Enok complex
FlyBase release FB2026_03 groups 4 D. melanogaster genes as enok complex (ENOK-C); this module models that group.
GO:0070776
MOZ/MORF histone acetyltransferase complex
GO term grounding the module as MOZ/MORF histone acetyltransferase complex.

A small four-subunit complex without known sub-structure; it is decomposed one part per subunit. FlyBase groups realized by this module: ENOK-C (FBgg0000604). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_enok_complex.yaml. Member genes with a gene review in this repository: Br140, Eaf6, enok, Ing5.

5Nodes
4Parts
0Variant Sets
0Variants
4Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_enok_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
dmel_enok_complex_enok_enok enok
UniProtKB:Q9W1A9
Gene 		histone acetyltransferase activity
GO:0004402 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (4/4 grounded genes reviewed)

3 complete review(s) · 4 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
Br140 Q7JVP4 ✓ ✓ ✓
Eaf6 Q9VRN3 ✓ 9/11 ✓
enok Q9W1A9 ✓ ✓ ✓
Ing5 Q9VJY8 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
chromatinGO:0000785
Enok complexProtein Complexdmel_enok_complex

MOZ/MORF-type complex of the Enok acetyltransferase with Br140, Ing5 and Eaf6.

MOZ/MORF histone acetyltransferase complexGO:0070776
Context
Drosophila melanogasterNCBITaxon:7227
chromatinGO:0000785
Part 1: bromodomain-PHD scaffold subunit
Br140Moduledmel_enok_complex_br140

Annotons

Br140 subunit
dmel_enok_complex_br140_br140
Participant: Gene Product: Br140
Gene Product:
Br140UniProtKB:Q7JVP4

bromodomain-PHD scaffold subunit

Part 2: Eaf6 subunit
Eaf6Moduledmel_enok_complex_eaf6

Annotons

Eaf6 subunit
dmel_enok_complex_eaf6_eaf6
Participant: Gene Product: Eaf6
Gene Product:
Eaf6UniProtKB:Q9VRN3

Eaf6 subunit

Part 3: ING-family histone reader subunit
Ing5Moduledmel_enok_complex_ing5

Annotons

Ing5 subunit
dmel_enok_complex_ing5_ing5
Participant: Gene Product: Ing5
Gene Product:
Ing5UniProtKB:Q9VJY8

ING-family histone reader subunit

Part 4: catalytic acetyltransferase subunit
enokModuledmel_enok_complex_enok

Annotons

enok subunit
dmel_enok_complex_enok_enok
Participant: Gene Product: enok
Gene Product:
enokUniProtKB:Q9W1A9

Function

histone acetyltransferase activityGO:0004402

catalytic acetyltransferase subunit