ER membrane protein complex (EMC) in Drosophila melanogaster

The ER membrane protein complex (EMC) is a multisubunit membrane protein insertase in the endoplasmic reticulum. It inserts tail-anchored proteins with moderately hydrophobic transmembrane segments and the first transmembrane segment of many multipass membrane proteins in the N-terminus out orientation, and it supports biogenesis of other multipass proteins. The conserved hydrophilic vestibule formed by EMC3 and EMC6 in the membrane carries out insertion, while the cytosolic EMC2 and EMC8/9 and the large lumenal EMC1, EMC7 and EMC10 subunits shape the complex. In Drosophila the EMC is required in photoreceptors for the biogenesis of rhodopsin and other multipass membrane proteins. Drosophila has two EMC2 paralogs, EMC2A and EMC2B, which FlyBase treats as alternative subunits.

MODULE:dmel_er_membrane_protein_complexDRAFTCONCRETEProtein Complexmodules/dmel_er_membrane_protein_complex.yaml

EMC complexGO:0072546

FB:FBgg0001811

FlyBase gene group EMPC: Er membrane protein complexes

FlyBase release FB2026_03 groups 10 D. melanogaster genes as er membrane protein complexes (EMPC); this module models that group.

GO:0072546

EMC complex

GO term grounding the module as EMC complex.

Decomposition. The subunits shared by both FlyBase variants form one part; EMC2A and EMC2B are alternatives. The insertase activity is assigned to EMC3, the core subunit of the insertion vestibule; EMC6 contributes to the same site. FlyBase groups realized by this module: EMPC (FBgg0001811). Subgroups folded into it: EMC, EMC2B. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_er_membrane_protein_complex.yaml. None of the member genes has a gene review in this repository yet.

5Nodes

2Parts

1Variant Sets

2Variants

3Annotons

0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_er_membrane_protein_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 1 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

Annoton	Participant	Function	Assessment
emc_shared_subunits_complex/emc3	EMC3 UniProtKB:Q9VKR0 Complex Unit	membrane insertase activity GO:0032977	Review Missing No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.

Gene-review completeness (0/10 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 10 missing review · 0 reviewed but lacking deep research

Gene	Review	Complete	Deep research
EMC7 A1ZA83	✗	—	—
EMC10 Q8IPT0	✗	—	—
EMC6 Q9VBZ8	✗	—	—
EMC2A Q9VEQ1	✗	—	—
EMC2B Q9VEQ2	✗	—	—
EMC1 Q9VHY6	✗	—	—
EMC5 Q9VJ25	✗	—	—
EMC3 Q9VKR0	✗	—	—
EMC4 Q9VNQ3	✗	—	—
EMC8-9 Q9W1Y1	✗	—	—

Tree

ER membrane protein complexProtein Complexdmel_er_membrane_protein_complex

Parts
1. 1. insertase core and structural subunits
2. Shared EMC subunitsProtein Complexemc_shared_subunits
  
  Annotons
  - Shared EMC subunits Protein Complex: Shared EMC subunits
3. 2. cytosolic EMC2 subunit
4. EMC2 subunitProtein Complexemc2_subunit
  
  Variants
  1. EMC2A or EMC2B (One Or More)
    
    EMC2AProtein Complexemc2a
    
    Annotons
    
    EMC2A EMC2A Gene Product: EMC2A
    
    EMC2BProtein Complexemc2b
    
    Annotons
    
    EMC2B EMC2B Gene Product: EMC2B

Details

Context

Drosophila melanogasterNCBITaxon:7227

endoplasmic reticulum membraneGO:0005789

ER membrane protein complexProtein Complexdmel_er_membrane_protein_complex

Multisubunit ER membrane insertase for tail-anchored and multipass membrane proteins, with EMC2A or EMC2B variants.

EMC complexGO:0072546

Context

Drosophila melanogasterNCBITaxon:7227

endoplasmic reticulum membraneGO:0005789

Part 1: insertase core and structural subunits

Shared EMC subunitsProtein Complexemc_shared_subunits

Annotons

Shared EMC subunits

emc_shared_subunits_complex

Participant: Protein Complex: Shared EMC subunits

Protein Complex:

Shared EMC subunits

Active units:

EMC1

Participant: Gene Product: EMC1

Gene Product:

EMC1UniProtKB:Q9VHY6

EMC3

Participant: Gene Product: EMC3

Gene Product:

EMC3UniProtKB:Q9VKR0

Function:

membrane insertase activityGO:0032977

EMC4

Participant: Gene Product: EMC4

Gene Product:

EMC4UniProtKB:Q9VNQ3

EMC5

Participant: Gene Product: EMC5

Gene Product:

EMC5UniProtKB:Q9VJ25

EMC6

Participant: Gene Product: EMC6

Gene Product:

EMC6UniProtKB:Q9VBZ8

EMC7

Participant: Gene Product: EMC7

Gene Product:

EMC7UniProtKB:A1ZA83

EMC8-9

Participant: Gene Product: EMC8-9

Gene Product:

EMC8-9UniProtKB:Q9W1Y1

EMC10

Participant: Gene Product: EMC10

Gene Product:

EMC10UniProtKB:Q8IPT0

Processes

tail-anchored membrane protein insertion into ER membraneGO:0071816

Part 2: cytosolic EMC2 subunit

EMC2 subunitProtein Complexemc2_subunit

Variant set: EMC2A or EMC2B (One Or More)

EMC2AProtein Complexemc2a

Annotons

EMC2A EMC2A

emc2a_emc2a

Participant: Gene Product: EMC2A

Gene Product:

EMC2AUniProtKB:Q9VEQ1

EMC2BProtein Complexemc2b

Annotons

EMC2B EMC2B

emc2b_emc2b

Participant: Gene Product: EMC2B

Gene Product:

EMC2BUniProtKB:Q9VEQ2