eRF1-eRF3 translation termination complex in Drosophila melanogaster

Eukaryotic translation termination is carried out by the release factors eRF1 and eRF3. eRF1 recognizes all three stop codons in the ribosomal A site and triggers hydrolysis of the peptidyl-tRNA bond through its conserved GGQ motif. eRF3 is a translational GTPase that delivers eRF1 to the ribosome as a ternary complex with GTP; GTP hydrolysis by eRF3 accommodates eRF1 and accelerates peptide release.

MODULE:dmel_erf1_erf3_termination_complexDRAFTCONCRETEProtein Complexmodules/dmel_erf1_erf3_termination_complex.yaml
translation release factor complexGO:0018444
FB:FBgg0001971
FlyBase gene group TRFC: Erf1-erf3 translation termination complex
FlyBase release FB2026_03 groups 2 D. melanogaster genes as erf1-erf3 translation termination complex (TRFC); this module models that group.
GO:0018444
translation release factor complex
GO term grounding the module as translation release factor complex.

Two-subunit complex modelled one part per subunit. Ribosome recycling (Pelo/ABCE1-type factors) is outside this module. FlyBase groups realized by this module: TRFC (FBgg0001971). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_erf1_erf3_termination_complex.yaml. Member genes with a gene review in this repository: eRF1, eRF3.

3Nodes
2Parts
0Variant Sets
0Variants
2Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_erf1_erf3_termination_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

2 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (2 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
erf1_subunit_erf1 eRF1
UniProtKB:Q9VPH7
Gene 		translation release factor activity
GO:0003747 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
erf3_subunit_erf3 eRF3
UniProtKB:Q9VK85
Gene 		GTPase activity
GO:0003924 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (2/2 grounded genes reviewed)

2 complete review(s) · 2 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
eRF1 Q9VPH7 ✓ ✓ ✓
eRF3 Q9VK85 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
eRF1-eRF3 termination complexProtein Complexdmel_erf1_erf3_termination_complex

Stop-codon-decoding eRF1 and the GTPase eRF3 that together terminate translation.

translation release factor complexGO:0018444
Context
Drosophila melanogasterNCBITaxon:7227
Part 1: stop-codon recognition and peptide release
eRF1 subunitProtein Complexerf1_subunit

Annotons

eRF1 eRF1 subunit
erf1_subunit_erf1
Participant: Gene Product: eRF1
Gene Product:
eRF1UniProtKB:Q9VPH7

Function

translation release factor activityGO:0003747

Processes

translational terminationGO:0006415
Part 2: GTPase that delivers eRF1 to the ribosome
eRF3 subunitProtein Complexerf3_subunit

Annotons

eRF3 eRF3 subunit
erf3_subunit_erf3
Participant: Gene Product: eRF3
Gene Product:
eRF3UniProtKB:Q9VK85

Function

GTPase activityGO:0003924

Processes

translational terminationGO:0006415