The exocyst is an octameric tethering complex that captures secretory and recycling vesicles at sites of exocytosis on the plasma membrane before SNARE-mediated fusion. Its eight subunits (Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84) are long helical-bundle proteins; Sec3 and Exo70 bind plasma membrane phosphoinositides and small GTPases, while Sec15 binds Rab11 on the vesicle. Structural studies divide the complex into two four-subunit modules, Sec3-Sec5-Sec6-Sec8 and Sec10-Sec15-Exo70-Exo84. In Drosophila the exocyst is required for polarized membrane delivery, for example to the rhabdomere of photoreceptors, to growing neurites and for epithelial junction protein trafficking.
Boundary. The module contains the eight exocyst subunits. Rab11, Ral and Rho-family GTPases that bind exocyst subunits, and the SNAREs that complete fusion, are partners, not parts. The two-subcomplex decomposition follows the structural organization described for yeast and mammalian exocyst. Vesicle membrane tethering activity (GO:7770062), which Sec8, Sec10 and Sec15 carry in GOA by IC and the other subunits by NAS, belongs to the assembled octamer and is recorded on a complex-level annoton with all eight subunits as active units. FlyBase groups realized by this module: EXOC (FBgg0000107). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_exocyst.yaml. None of the member genes has a gene review in this repository yet.
proposed_ontology_changes[0] · supported_by
(0/1)proposed_ontology_changes[3] · supported_by
(0/1)proposed_ontology_changes[4] · supported_by
(0/1)✗ none found
No MODULE:dmel_exocyst deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| dmel_exocyst_complex_activity | PROTEIN_COMPLEX Gene |
vesicle membrane tethering activity GO:7770062 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
0 complete review(s) · 0 with deep research · 8 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Exo84 Q7KRZ3 | ✗ | — | — |
| Sec6 Q9V8K2 | ✗ | — | — |
| Sec15 Q9VDE6 | ✗ | — | — |
| Sec8 Q9VNH6 | ✗ | — | — |
| Sec5 Q9VQQ9 | ✗ | — | — |
| Exo70 Q9VSJ8 | ✗ | — | — |
| Sec3 Q9VVG4 | ✗ | — | — |
| Sec10 Q9XTM1 | ✗ | — | — |
Octameric complex that tethers secretory and recycling vesicles to the plasma membrane for exocytosis.
Tethers secretory vesicles to the plasma membrane at sites of exocytosis before SNARE-mediated fusion.