Capping protein is an alpha/beta heterodimer that binds the barbed (plus) end of actin filaments with high affinity and blocks the addition and loss of actin subunits there. It limits filament elongation, which shapes branched actin networks and controls the length of actin structures. In Drosophila the alpha (cpa) and beta (cpb) subunits are each required to restrict actin filament growth, for example in bristle development and in the germline, and loss of either subunit destabilizes the other. The same heterodimer also caps the barbed end of the Arp1 filament of dynactin.
cpa and cpb are also members of the FlyBase dynactin complex group, where the heterodimer caps the Arp1 filament; they appear in both modules. The barbed-end capping activity belongs to the heterodimer as a whole, so no molecular function is assigned to the individual subunits. The GO barbed-end actin capping activity terms are obsolete, so no complex-level molecular function is assigned either. FlyBase groups realized by this module: ACPC (FBgg0001737). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_f_actin_capping_protein.yaml. Member genes with a gene review in this repository: cpa, cpb.
All recommended fields populated.
✗ none found
No MODULE:dmel_f_actin_capping_protein deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
2 complete review(s) · 2 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| cpa Q9W2N0 | ✓ | ✓ | ✓ |
| cpb P48603 | ✓ | ✓ | ✓ |
Alpha/beta heterodimer that caps actin filament barbed ends.