Drosophila has two FGF receptor tyrosine kinases with distinct ligands. Breathless (Btl) is activated by Branchless (Bnl) and guides tracheal branch migration, and Heartless (Htl) is activated by Pyramus and Thisbe and directs the spreading and migration of mesoderm and glial cells. Both receptors use the FGFR-specific cytoplasmic adaptor Stumps (Downstream of FGFR, Dof). Signaling proceeds through Drk, Sos, Ras85D and the Raf-Dsor1-Rolled MAP kinase cascade, ending in ETS factor output (Pointed activation, Yan/Aop relief). Pebble, a Rho exchange factor, acts in Heartless-dependent mesoderm migration.
Boundary. Core components only (FlyBase FGFR-C). The adaptors, Ras and the MAP kinase cascade are shared with EGFR, Sevenless and Torso signaling. Heparan sulfate proteoglycans (Dally, Dlp, Trol), Sprouty and other FlyBase regulators are not parts. FlyBase groups realized by this module: FGFR (FBgg0000967). Subgroups folded into it: FGFR-C. FlyBase also curates regulator sets for this pathway, which are context and not modelled as parts: FGFR-N (negative regulators of fgfr signaling pathway, 7 genes); FGFR-P (positive regulators of fgfr signaling pathway, 7 genes). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_fgfr_signaling.yaml. Member genes with a gene review in this repository: drk, Dsor1, Raf, Ras85D, rl, Sos.
All recommended fields populated.
✗ none found
No MODULE:dmel_fgfr_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
6 gene-function check(s) reflected in core functions · 0 conflict(s) · 7 evidence or coverage gap(s) (13 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| breathless_branch_bnl | bnl UniProtKB:Q9VDT9 Gene |
growth factor activity GO:0008083 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| breathless_branch_btl | btl UniProtKB:Q09147 Gene |
fibroblast growth factor receptor activity GO:0005007 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| heartless_branch_pyr | pyr UniProtKB:B9ZW35 Gene |
growth factor activity GO:0008083 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| heartless_branch_ths | ths UniProtKB:A0A0B4K7X1 Gene |
growth factor activity GO:0008083 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| heartless_branch_htl | htl UniProtKB:Q07407 Gene |
fibroblast growth factor receptor activity GO:0005007 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| fgfr_adaptors_and_ras_activation_csw | csw UniProtKB:P29349 Gene |
protein tyrosine phosphatase activity GO:0004725 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| fgfr_adaptors_and_ras_activation_sos | Sos UniProtKB:P26675 Gene |
guanyl-nucleotide exchange factor activity GO:0005085 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| fgfr_ras_ras85d | Ras85D UniProtKB:P08646 Gene |
GTPase activity GO:0003924 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| fgfr_mapk_cascade_raf | Raf UniProtKB:P11346 Gene |
MAP kinase kinase kinase activity GO:0004709 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| fgfr_mapk_cascade_dsor1 | Dsor1 UniProtKB:Q24324 Gene |
MAP kinase kinase activity GO:0004708 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| fgfr_mapk_cascade_rl | rl UniProtKB:P40417 Gene |
MAP kinase activity GO:0004707 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| fgfr_nuclear_output_pnt | pnt UniProtKB:P51023 Gene |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| fgfr_nuclear_output_aop | aop UniProtKB:Q01842 Gene |
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
3 complete review(s) · 7 with deep research · 14 missing review · 1 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| ths A0A0B4K7X1 | ✗ | — | — |
| cnk A1ZAS2 | ✗ | — | — |
| pyr B9ZW35 | ✗ | — | — |
| btl Q09147 | ✓ | 90/91 | ✓ |
| drk Q08012 | ✓ | 74/76 | ✓ |
| Dsor1 Q24324 | ✓ | ✓ | ✓ |
| grh P13002 | ✗ | — | — |
| gro P16371 | ✗ | — | — |
| csw P29349 | ✗ | — | — |
| pnt P51023 | ✗ | — | — |
| aop Q01842 | ✗ | — | — |
| htl Q07407 | ✗ | — | — |
| ksr Q24171 | ✗ | — | — |
| pbl Q8IQ97 | ✗ | — | — |
| Shc Q9V3C8 | ✗ | — | — |
| bnl Q9VDT9 | ✗ | — | — |
| stumps Q9VFI0 | ✗ | — | — |
| Raf P11346 | ✓ | 89/90 | ✓ |
| Ras85D P08646 | ✓ | ✓ | ✓ |
| rl P40417 | ✓ | 119/125 | ✓ |
| Sos P26675 | ✓ | 47/50 | ✗ |
| Zpr1 Q9W379 | ✓ | ✓ | ✓ |
Branchless-Breathless and Pyramus/Thisbe-Heartless FGF signaling through Stumps, Ras and the Raf-Dsor1-Rolled cascade to ETS transcriptional output.
Tracheal FGF signaling.
Mesodermal and glial FGF signaling.
Stumps (Dof) is the FGFR-specific adaptor; Drk, Shc, Corkscrew (SHP2) and Sos link the receptors to Ras.
Pointed (activator) and Yan/Aop (repressor) are ETS factors acting downstream of ERK. Grainyhead, Groucho and Zpr1 are FlyBase core components whose roles in FGFR signaling are less defined.