The serine/threonine kinase Fused, best known as a Hedgehog pathway component, also forms a complex with the HECT-domain E3 ubiquitin ligase Smurf. In the Drosophila ovary germline stem cell niche, the Fused-Smurf complex promotes ubiquitylation and degradation of the BMP type I receptor Thickveins in cells displaced from the niche, sharpening the BMP response and allowing stem cell daughters to differentiate.
GO has no specific term for the Fused-Smurf complex; the module is grounded to the generic ubiquitin ligase complex term. Fused's role in Hedgehog signalling is a separate function outside this module. FlyBase groups realized by this module: FUSF (FBgg0001802). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_fused_smurf_complex.yaml. Member genes with a gene review in this repository: fu, Smurf.
All recommended fields populated.
✗ none found
No MODULE:dmel_fused_smurf_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
2 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (2 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| dmel_fused_smurf_complex_smurf_smurf | Smurf UniProtKB:Q9V853 Gene |
ubiquitin protein ligase activity GO:0061630 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| dmel_fused_smurf_complex_fu_fu | fu UniProtKB:P23647 Gene |
protein serine/threonine kinase activity GO:0004674 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
2 complete review(s) · 2 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| fu P23647 | ✓ | ✓ | ✓ |
| Smurf Q9V853 | ✓ | ✓ | ✓ |
Fused kinase and the HECT E3 ligase Smurf, which together downregulate the BMP receptor Thickveins.
Smurf HECT E3 ubiquitin ligase
Fused serine/threonine kinase