Gamma-secretase complex in Drosophila melanogaster

Gamma-secretase is an intramembrane aspartyl protease that cleaves type I membrane proteins within their transmembrane domains after their ectodomains have been shed. Presenilin (Psn) is the catalytic subunit and carries the two catalytic aspartates; nicastrin (Nct), Aph-1 and Pen-2 are required for assembly, maturation and activity. In Drosophila the complex performs the S3 cleavage of Notch that releases the Notch intracellular domain, so loss of its subunits causes Notch-like phenotypes.

MODULE:dmel_gamma_secretase_complexDRAFTCONCRETEProtein Complexmodules/dmel_gamma_secretase_complex.yaml
gamma-secretase complexGO:0070765
FB:FBgg0001062
FlyBase gene group GSC: Gamma secretase complex
FlyBase release FB2026_03 groups 4 D. melanogaster genes as gamma secretase complex (GSC); this module models that group.
GO:0070765
gamma-secretase complex
GO term grounding the module as gamma-secretase complex.

Presenilin autoproteolysis into N- and C-terminal fragments, promoted by Pen-2, is part of complex maturation. Gamma-secretase substrates other than Notch are not modelled. FlyBase groups realized by this module: GSC (FBgg0001062). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_gamma_secretase_complex.yaml. Member genes with a gene review in this repository: aph-1, Nct, pen-2, Psn.

3Nodes
2Parts
0Variant Sets
0Variants
2Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_gamma_secretase_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
catalytic_subunit_psn Psn
UniProtKB:O02194
Gene 		aspartic-type endopeptidase activity
GO:0004190 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (4/4 grounded genes reviewed)

4 complete review(s) · 4 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
aph-1 Q9VQG2 ✓ ✓ ✓
Nct Q9VC27 ✓ ✓ ✓
pen-2 Q86BE9 ✓ ✓ ✓
Psn O02194 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
Gamma-secretase complexProtein Complexdmel_gamma_secretase_complex

Four-subunit intramembrane aspartyl protease (Psn, Nct, aph-1, pen-2) that releases the Notch intracellular domain.

gamma-secretase complexGO:0070765
Context
Drosophila melanogasterNCBITaxon:7227
Part 1: catalytic subunit
PresenilinProtein Complexcatalytic_subunit

Annotons

Psn Presenilin
catalytic_subunit_psn
Participant: Gene Product: Psn
Gene Product:
PsnUniProtKB:O02194

Function

aspartic-type endopeptidase activityGO:0004190
Part 2: assembly and substrate-recognition subunits
Nicastrin, Aph-1 and Pen-2Protein Complexaccessory_subunits

Annotons

Nicastrin, Aph-1 and Pen-2
accessory_subunits_complex
Participant: Protein Complex: Nicastrin, Aph-1 and Pen-2
Protein Complex:
Nicastrin, Aph-1 and Pen-2
Active units:
Nct
Participant: Gene Product: Nct
Gene Product:
NctUniProtKB:Q9VC27
aph-1
Participant: Gene Product: aph-1
Gene Product:
aph-1UniProtKB:Q9VQG2
pen-2
Participant: Gene Product: pen-2
Gene Product:
pen-2UniProtKB:Q86BE9