Gamma-tubulin complexes in Drosophila melanogaster

Gamma-tubulin complexes nucleate microtubules at centrosomes, spindles and other microtubule-organizing centres. The basic unit is the gamma-tubulin small complex (gamma-TuSC), two gamma-tubulin molecules bound to Grip84 (GCP2) and Grip91 (GCP3). In the larger gamma-tubulin ring complex (gamma-TuRC), several gamma-TuSCs assemble with additional GCP-family proteins (Grip75, Grip128, Grip163) and Grip71 into a ring that templates the 13-protofilament microtubule. Drosophila has two gamma-tubulins: gammaTub23C, used in most tissues, and gammaTub37C, which is maternally supplied and acts in the female germline and early embryo. In the testis a separate gamma-TuRC built from testis-specific t-Grip84, t-Grip91 and t-Grip128 paralogs acts in spermatogenesis.

MODULE:dmel_gamma_tubulin_complexesDRAFTCONCRETEProtein Complexmodules/dmel_gamma_tubulin_complexes.yaml
gamma-tubulin complexGO:0000930
FB:FBgg0001769
FlyBase gene group G-TUC: Gamma-tubulin complexes
FlyBase release FB2026_03 groups 11 D. melanogaster genes as gamma-tubulin complexes (G-TUC); this module models that group.
GO:0000930
gamma-tubulin complex
GO term grounding the module as gamma-tubulin complex.

The FlyBase subgroups G-TUSC, G-TURC and T-G-TURC share subunits; the gamma-TuSC is modelled as the core part and the two ring complexes as variants, so shared subunits appear more than once. Grip71 (NEDD1 homolog) is included because FlyBase places it in the gamma-TuRC; in other systems its homolog acts mainly as a targeting factor for the ring complex. Ring attachment factors such as the augmin complex (dmel_augmin_complex) and centrosomal tethers are not parts. The gamma-tubulins are given microtubule nucleator activity (GO:0140490), which both paralogs carry in GOA (IBA); the Grip proteins carry gamma-tubulin and microtubule minus-end binding terms and are left without an annoton function. FlyBase groups realized by this module: G-TUC (FBgg0001769). Subgroups folded into it: G-TUSC, T-G-TURC, G-TURC. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_gamma_tubulin_complexes.yaml. None of the member genes has a gene review in this repository yet.

5Nodes
2Parts
1Variant Sets
2Variants
3Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_gamma_tubulin_complexes deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 5 evidence or coverage gap(s) (5 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
gamma_tusc_complex/gammatub23c gammaTub23C
UniProtKB:P23257
Complex Unit 		microtubule nucleator activity
GO:0140490 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
gamma_tusc_complex/gammatub37c gammaTub37C
UniProtKB:P42271
Complex Unit 		microtubule nucleator activity
GO:0140490 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
somatic_gamma_turc_complex/gammatub23c gammaTub23C
UniProtKB:P23257
Complex Unit 		microtubule nucleator activity
GO:0140490 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
somatic_gamma_turc_complex/gammatub37c gammaTub37C
UniProtKB:P42271
Complex Unit 		microtubule nucleator activity
GO:0140490 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
testis_gamma_turc_complex/gammatub23c gammaTub23C
UniProtKB:P23257
Complex Unit 		microtubule nucleator activity
GO:0140490 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.

Gene-review completeness (0/11 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 11 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
gammaTub23C P23257 ✗ — —
gammaTub37C P42271 ✗ — —
t-Grip91 Q4LDP4 ✗ — —
t-Grip128 Q8IRA1 ✗ — —
Grip71 Q9VJ57 ✗ — —
Grip75 Q9VKU7 ✗ — —
t-Grip84 Q9VS91 ✗ — —
Grip163 Q9VTS3 ✗ — —
Grip128 Q9VXU8 ✗ — —
Grip84 Q9XYP7 ✗ — —
Grip91 Q9XYP8 ✗ — —

Details

Context
Drosophila melanogasterNCBITaxon:7227
Gamma-tubulin complexesProtein Complexdmel_gamma_tubulin_complexes

Gamma-tubulin small and ring complexes, including a testis-specific ring complex, that nucleate microtubules.

gamma-tubulin complexGO:0000930
Context
Drosophila melanogasterNCBITaxon:7227
Part 1: core nucleating unit
Gamma-tubulin small complexProtein Complexgamma_tusc

Gamma-tubulin with Grip84 and Grip91. Either gamma-tubulin paralog (gammaTub23C or gammaTub37C) can occupy the gamma-tubulin positions, depending on tissue.

Annotons

Gamma-tubulin small complex
gamma_tusc_complex
Participant: Protein Complex: Gamma-tubulin small complex
Protein Complex:
Gamma-tubulin small complexGO:0008275
Active units:
Grip84
Participant: Gene Product: Grip84
Gene Product:
Grip84UniProtKB:Q9XYP7
Grip91
Participant: Gene Product: Grip91
Gene Product:
Grip91UniProtKB:Q9XYP8
gammaTub23C
Participant: Gene Product: gammaTub23C
Gene Product:
gammaTub23CUniProtKB:P23257
Function:
microtubule nucleator activityGO:0140490
gammaTub37C
Participant: Gene Product: gammaTub37C
Gene Product:
gammaTub37CUniProtKB:P42271
Function:
microtubule nucleator activityGO:0140490

Processes

microtubule nucleationGO:0007020
Part 2: ring-shaped microtubule template
Gamma-tubulin ring complexesProtein Complexgamma_turc
Variant set: Somatic or testis-specific gamma-TuRC (One Or More)
Gamma-tubulin ring complexProtein Complexsomatic_gamma_turc

Gamma-TuSC subunits plus Grip75, Grip128, Grip163 and Grip71.

Annotons

Gamma-tubulin ring complex
somatic_gamma_turc_complex
Participant: Protein Complex: Gamma-tubulin ring complex
Protein Complex:
Gamma-tubulin ring complexGO:0000931
Active units:
Grip128
Participant: Gene Product: Grip128
Gene Product:
Grip128UniProtKB:Q9VXU8
Grip163
Participant: Gene Product: Grip163
Gene Product:
Grip163UniProtKB:Q9VTS3
Grip71
Participant: Gene Product: Grip71
Gene Product:
Grip71UniProtKB:Q9VJ57
Grip75
Participant: Gene Product: Grip75
Gene Product:
Grip75UniProtKB:Q9VKU7
Grip84
Participant: Gene Product: Grip84
Gene Product:
Grip84UniProtKB:Q9XYP7
Grip91
Participant: Gene Product: Grip91
Gene Product:
Grip91UniProtKB:Q9XYP8
gammaTub23C
Participant: Gene Product: gammaTub23C
Gene Product:
gammaTub23CUniProtKB:P23257
Function:
microtubule nucleator activityGO:0140490
gammaTub37C
Participant: Gene Product: gammaTub37C
Gene Product:
gammaTub37CUniProtKB:P42271
Function:
microtubule nucleator activityGO:0140490

Processes

microtubule nucleationGO:0007020
Testis-specific gamma-tubulin ring complexProtein Complextestis_gamma_turc

Ring complex of gammaTub23C with the testis-specific paralogs t-Grip84, t-Grip91 and t-Grip128.

Annotons

Testis-specific gamma-tubulin ring complex
testis_gamma_turc_complex
Participant: Protein Complex: Testis-specific gamma-tubulin ring complex
Protein Complex:
Testis-specific gamma-tubulin ring complexGO:0000931
Active units:
gammaTub23C
Participant: Gene Product: gammaTub23C
Gene Product:
gammaTub23CUniProtKB:P23257
Function:
microtubule nucleator activityGO:0140490
t-Grip128
Participant: Gene Product: t-Grip128
Gene Product:
t-Grip128UniProtKB:Q8IRA1
t-Grip84
Participant: Gene Product: t-Grip84
Gene Product:
t-Grip84UniProtKB:Q9VS91
t-Grip91
Participant: Gene Product: t-Grip91
Gene Product:
t-Grip91UniProtKB:Q4LDP4

Processes

microtubule nucleationGO:0007020