The Golgi-associated retrograde protein (GARP) complex and the endosome-associated recycling protein (EARP) complex are related multisubunit tethering complexes that share Vps51, Vps52 and Vps53. GARP contains Vps54 (scattered, scat, in Drosophila) and tethers endosome-derived vesicles at the trans-Golgi network, supporting retrograde transport of cargo such as lysosomal hydrolase receptors. EARP contains Vps50 in place of Vps54 and acts in recycling from endosomes to the plasma membrane. Drosophila scat mutants are male sterile, with defects in spermatid differentiation.
Boundary. The module contains the two FlyBase-curated complexes, modelled as alternative variants that share the Vps51-Vps52-Vps53 core. No molecular function is assigned: GARP and EARP are tethering complexes, but the GO vesicle membrane tethering activity term is not annotated to their fly subunits, which carry only SNARE, syntaxin and small GTPase binding terms. FlyBase groups realized by this module: GARP (FBgg0000466). Subgroups folded into it: GARPI, GARPII. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_garp_complex.yaml. Member genes with a gene review in this repository: scat, Vps50, Vps51, Vps52, Vps53.
All recommended fields populated.
✗ none found
No MODULE:dmel_garp_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
5 complete review(s) · 5 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| scat Q9VLC0 | ✓ | ✓ | ✓ |
| Vps50 A1ZAY8 | ✓ | ✓ | ✓ |
| Vps51 Q8MSY4 | ✓ | ✓ | ✓ |
| Vps52 Q9VMQ8 | ✓ | ✓ | ✓ |
| Vps53 Q9VQY8 | ✓ | ✓ | ✓ |
Two related tethering complexes sharing Vps51-Vps53: GARP (with Vps54) for endosome-to-Golgi retrograde transport and EARP (with Vps50) for endocytic recycling.
Vps51-Vps52-Vps53 with Vps54 (scat).
Vps51-Vps52-Vps53 with Vps50.