Gcn5-containing histone acetyltransferase complexes in Drosophila melanogaster
The histone acetyltransferase Gcn5 acetylates histone H3 as the catalytic subunit of several coactivator complexes. Gcn5 always sits in a HAT module with Ada3, Sgf29 and an Ada2 paralog. With Ada2b it forms part of SAGA, a large coactivator that also contains a TBP-interacting core, the Tra1 homolog Nipped-A, and a deubiquitinase module that removes ubiquitin from histone H2B through the protease Nonstop. With Ada2a it forms ATAC, which also contains the Atac1-3 subunits. Smaller ADA and CHAT (Chiffon-containing) complexes contain only the HAT module, with Chiffon in CHAT.
The four FlyBase subgroups are modelled as alternative complexes, so shared HAT-module subunits appear in each. SAGA is decomposed into its HAT, deubiquitinase, core, Tra1 and SF3B parts; within the core, assignment of the two Ada1 paralogs and Wda follows their FlyBase membership of SAGA and is not meant to resolve finer architecture. ATAC also contains Hcf, Wds, Chrac-14, NC2beta and Mocs2B as listed by FlyBase. FlyBase groups realized by this module: GCN5 (FBgg0001748). Subgroups folded into it: ATAC, SAGA, ADAC, CHAT. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_gcn5_acetyltransferase_complexes.yaml. None of the member genes has a gene review in this repository yet.
Derived QC
Recommended-field compliance
All recommended fields populated.
Module deep research
✗ none found
No MODULE:dmel_gcn5_acetyltransferase_complexes deep-research report alongside the module YAML.
Leaf nodes lacking representative members
✓ every leaf node grounds to a representative protein.
Template conformance
✓ every declared conforms_to bundle matches its template motif.
Function consistency and core coverage
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 5 evidence or coverage gap(s) (5 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| saga_hat_module_complex/gcn5 | Gcn5 UniProtKB:Q9VTZ1 Complex Unit |
histone acetyltransferase activity GO:0004402 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| saga_dub_module_complex/not | not UniProtKB:Q9VVR1 Complex Unit |
histone H2B deubiquitinase activity GO:0140936 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| atac_complex/gcn5 | Gcn5 UniProtKB:Q9VTZ1 Complex Unit |
histone acetyltransferase activity GO:0004402 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| ada_complex/gcn5 | Gcn5 UniProtKB:Q9VTZ1 Complex Unit |
histone acetyltransferase activity GO:0004402 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| chat_complex/gcn5 | Gcn5 UniProtKB:Q9VTZ1 Complex Unit |
histone acetyltransferase activity GO:0004402 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
Gene-review completeness (0/32 grounded genes reviewed)
0 complete review(s) · 0 with deep research · 32 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Atac3 M9NFF9 | ✗ | — | — |
| Ada3 M9PHZ1 | ✗ | — | — |
| Taf12 P49905 | ✗ | — | — |
| Taf9 Q27272 | ✗ | — | — |
| Ada2a Q7KSD8 | ✗ | — | — |
| Nipped-A Q8I8U7 | ✗ | — | — |
| Ada2b Q8I8V0 | ✗ | — | — |
| Ada1-1 Q8IP99 | ✗ | — | — |
| Ada1-2 Q8IPA1 | ✗ | — | — |
| chif Q9NK54 | ✗ | — | — |
| wds Q9V3J8 | ✗ | — | — |
| Chrac-14 Q9V444 | ✗ | — | — |
| Hcf Q9V4C8 | ✗ | — | — |
| Mocs2B Q9VBX2 | ✗ | — | — |
| wda Q9VCN9 | ✗ | — | — |
| Spt3 Q9VGE2 | ✗ | — | — |
| Sf3b5 Q9VHI4 | ✗ | — | — |
| Atac2 Q9VJ73 | ✗ | — | — |
| NC2beta Q9VJQ5 | ✗ | — | — |
| Yeats2 Q9VLL1 | ✗ | — | — |
| Atac1 Q9VM59 | ✗ | — | — |
| Saf6 Q9VPT4 | ✗ | — | — |
| Atxn7 Q9VQB6 | ✗ | — | — |
| Gcn5 Q9VTZ1 | ✗ | — | — |
| Spt20 Q9VU86 | ✗ | — | — |
| not Q9VVR1 | ✗ | — | — |
| Sgf11 Q9VVR6 | ✗ | — | — |
| Spt7 Q9VX12 | ✗ | — | — |
| e(y)2 Q9VYX1 | ✗ | — | — |
| Sf3b3 Q9W0M7 | ✗ | — | — |
| Sgf29 Q9W2I4 | ✗ | — | — |
| Taf10b Q9XZT7 | ✗ | — | — |
Details
SAGA, ATAC, ADA and CHAT coactivator complexes that share the Gcn5 histone acetyltransferase module.