HOPS and CORVET are related hexameric tethering complexes of the endolysosomal system that share a class C Vps core of Vps11, Vps16, Vps18 and the Sec1/Munc18-family protein Vps33. HOPS adds Vps39 and Vps41, binds active Rab7 and promotes SNARE-dependent fusion of late endosomes, autophagosomes and lysosome-related organelles with lysosomes. CORVET uses Vps8 (with Vps3 in yeast and mammals) and acts at the Rab5-positive early endosome stage. In Drosophila the core subunits are encoded by Vps11, Vps16A, deep orange (dor, Vps18) and carnation (car, Vps33A), and the HOPS-specific subunits by Vps39 and light (lt, Vps41); several of these were identified as eye-colour mutants with pigment granule defects. Drosophila also has paralogs Vps16B and Vps33B, which form a separate complex related to the mammalian VPS33B-VIPAS39 (CHEVI) complex.
Decomposition. The class C core, the HOPS-specific pair and the CORVET-specific Vps8 are modelled as parts; Drosophila has no Vps3 ortholog, and the exact subunit composition of Drosophila CORVET-like complexes is not modelled beyond Vps8. Vps16B and Vps33B are included because FlyBase groups them with the Vps-C subunits; they are modelled as a separate part because they do not form HOPS. Rab7, the Mon1-Ccz1 Rab7 exchange factor and the lysosomal SNAREs are partners, not parts. No molecular function is assigned: the fly subunits carry no tethering activity term, and the ubiquitin ligase activity inferred for the RING-domain subunits Vps11 and Dor (ISS) is not established for the fly proteins. FlyBase groups realized by this module: VPS-C (FBgg0000106). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_hops_corvet_tethering.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_hops_corvet_tethering deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
0 complete review(s) · 0 with deep research · 9 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| dor Q24314 | ✗ | — | — |
| lt Q7PL76 | ✗ | — | — |
| Vps11 Q8SX81 | ✗ | — | — |
| Vps16B Q9VAG4 | ✗ | — | — |
| Vps33B Q9VBR1 | ✗ | — | — |
| Vps39 Q9VEA2 | ✗ | — | — |
| Vps16A Q9VHG1 | ✗ | — | — |
| Vps8 Q9VRX2 | ✗ | — | — |
| car Q9Y1I2 | ✗ | — | — |
Class C Vps core with HOPS-specific (Vps39, Vps41) and CORVET-specific (Vps8) subunits that tether endosomes, autophagosomes and lysosomes for fusion.
Vps11, Vps16A, Vps18 (dor) and the SM protein Vps33A (car).
Vps39 and Vps41 (lt), which confer late endosome and lysosome specificity.