The INO80 complex is an ATP-dependent chromatin remodeler of the INO80 subfamily that slides nucleosomes and positions the +1 nucleosome at promoters, and contributes to transcription regulation and DNA repair. In Drosophila it contains the Ino80 ATPase, the AAA+ ATPases Pontin and Reptin, actin and the actin-related proteins Arp5 and Arp8. FlyBase also places the Polycomb group DNA-binding protein Pho (the YY1 homolog) in the complex, consistent with a role of INO80 in recruiting Polycomb proteins.
Grouping of actin, Arp5 and Arp8 together is a coarse simplification; in yeast Arp8 and actin bind the HSA region while Arp5 binds the ATPase. Pho is included because FlyBase lists it as an INO80 subunit; it is also modelled in the PhoRC part of dmel_polycomb_group_complexes. FlyBase groups realized by this module: INO80 (FBgg0000291). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_ino80_complex.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_ino80_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 1 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| ino80_atpase_ino80 | Ino80 UniProtKB:Q9VDY1 Gene |
ATP-dependent chromatin remodeler activity GO:0140658 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
0 complete review(s) · 0 with deep research · 7 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Act5C P10987 | ✗ | — | — |
| pho Q8ST83 | ✗ | — | — |
| rept Q9V3K3 | ✗ | — | — |
| Ino80 Q9VDY1 | ✗ | — | — |
| Arp5 Q9VEC3 | ✗ | — | — |
| pont Q9VH07 | ✗ | — | — |
| Arp8 Q9VX09 | ✗ | — | — |
Ino80 ATPase complex with Pontin, Reptin, actin, Arp5, Arp8 and Pho.