Intraflagellar transport (IFT) moves protein cargo along the axoneme between the ciliary base and tip. IFT trains are built from two multi-subunit complexes: IFT-B, which is carried toward the tip by kinesin-2 and is required for anterograde transport and axoneme assembly, and IFT-A, which is needed mainly for retrograde transport by cytoplasmic dynein 2 and for import of membrane proteins. In Drosophila, cilia occur only on type I sensory neurons and on sperm. IFT is required to build the sensory cilia of chordotonal and external sensory neurons, and mutants such as nompB (IFT88) lack mechanosensory potentials, whereas most of the sperm axoneme is assembled without IFT.
The BBSome subgroup (BBS) of the FlyBase IFT group is already covered by the existing bbsome module and is not repeated here. IFT-B is not split into its IFT-B1 and IFT-B2 subcomplexes because not all Drosophila members have been mapped to them. Kinesin-2 and cytoplasmic dynein 2 motors (see dmel_cytoplasmic_dynein_dynactin) are context, not parts. No molecular function is assigned: IFT-A and IFT-B are adaptor and scaffold complexes that link ciliary cargo to kinesin-2 and dynein-2 motors, and most Drosophila IFT subunits have only ND molecular function annotations in GOA. FlyBase groups realized by this module: IFT (FBgg0000046). Subgroups folded into it: IFT-A, IFT-B. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_intraflagellar_transport.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_intraflagellar_transport deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
0 complete review(s) · 0 with deep research · 16 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| IFT20 A1Z6F0 | ✗ | — | — |
| Oseg6 A1ZBM3 | ✗ | — | — |
| nompB Q7KRS6 | ✗ | — | — |
| rempA Q7KTZ4 | ✗ | — | — |
| Ttc26 Q9VF41 | ✗ | — | — |
| IFT54 Q9VFL0 | ✗ | — | — |
| Oseg5 Q9VII8 | ✗ | — | — |
| IFT46 Q9VJ72 | ✗ | — | — |
| Ttc30 Q9VK41 | ✗ | — | — |
| IFT43 Q9VK67 | ✗ | — | — |
| IFT52 Q9VMC0 | ✗ | — | — |
| IFT57 Q9VQS5 | ✗ | — | — |
| Cluap1 Q9VR64 | ✗ | — | — |
| Oseg1 Q9VSJ6 | ✗ | — | — |
| Oseg2 Q9W040 | ✗ | — | — |
| Oseg4 Q9W097 | ✗ | — | — |
IFT-A and IFT-B complexes that move cargo along sensory neuron cilia and are required to assemble them.