ISWI chromatin remodeling complexes in Drosophila melanogaster

ISWI is an ATP-dependent chromatin remodeler that slides nucleosomes. In Drosophila the single ISWI ATPase is the catalytic subunit of several complexes defined by their accessory subunits. ACF (with Acf) and CHRAC (Acf plus the histone-fold pair Chrac-14 and Chrac-16) assemble and space regularly arrayed nucleosomes. NURF (with the large subunit E(bx)/NURF301, Caf1-55 and the pyrophosphatase Nurf-38) helps activate transcription of target genes, for example in ecdysone and JAK/STAT signaling. RSF, NORC and TORC (with Toutatis and CtBP) are further ISWI complexes; TORC is linked to transcriptional repression.

MODULE:dmel_iswi_complexesDRAFTCONCRETEProtein Complexmodules/dmel_iswi_complexes.yaml
ISWI-type complexGO:0031010
FB:FBgg0000314
FlyBase gene group ISWI: Iswi complexes
FlyBase release FB2026_03 groups 10 D. melanogaster genes as iswi complexes (ISWI); this module models that group.
GO:0031010
ISWI-type complex
GO term grounding the module as ISWI-type complex.

The six FlyBase subgroups are modelled as alternative complexes, so Iswi appears in each. RSF contains CG8677 (the Drosophila RSF1 homolog per FlyBase). TORC has no specific GO term and is grounded to ISWI-type complex. FlyBase groups realized by this module: ISWI (FBgg0000314). Subgroups folded into it: NURF, NORC, ACF, CHRAC, TORC, RSF. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_iswi_complexes.yaml. Member genes with a gene review in this repository: Caf1-55.

7Nodes
0Parts
1Variant Sets
6Variants
6Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_iswi_complexes deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 7 evidence or coverage gap(s) (7 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
nurf_complex/iswi Iswi
UniProtKB:Q24368
Complex Unit 		ATP-dependent chromatin remodeler activity
GO:0140658 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
nurf_complex/nurf_38 Nurf-38
UniProtKB:O77460
Complex Unit 		inorganic diphosphate phosphatase activity
GO:0004427 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
acf_complex/iswi Iswi
UniProtKB:Q24368
Complex Unit 		ATP-dependent chromatin remodeler activity
GO:0140658 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
chrac_complex/iswi Iswi
UniProtKB:Q24368
Complex Unit 		ATP-dependent chromatin remodeler activity
GO:0140658 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
rsf_complex/iswi Iswi
UniProtKB:Q24368
Complex Unit 		ATP-dependent chromatin remodeler activity
GO:0140658 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
norc_complex/iswi Iswi
UniProtKB:Q24368
Complex Unit 		ATP-dependent chromatin remodeler activity
GO:0140658 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
torc_complex/iswi Iswi
UniProtKB:Q24368
Complex Unit 		ATP-dependent chromatin remodeler activity
GO:0140658 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.

Gene-review completeness (1/10 grounded genes reviewed)

0 complete review(s) · 1 with deep research · 9 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
tou A8DYA3 ✗ — —
Caf1-55 Q24572 ✓ 90/91 ✓
CtBP O46036 ✗ — —
Nurf-38 O77460 ✗ — —
Iswi Q24368 ✗ — —
Chrac-14 Q9V444 ✗ — —
Chrac-16 Q9V452 ✗ — —
Acf Q9V9T4 ✗ — —
CG8677 Q9VID9 ✗ — —
E(bx) Q9W0T1 ✗ — —

Details

Context
Drosophila melanogasterNCBITaxon:7227
chromatinGO:0000785
ISWI complexesProtein Complexdmel_iswi_complexes

ACF, CHRAC, NURF, RSF, NORC and TORC remodelers that share the ISWI ATPase.

ISWI-type complexGO:0031010
Context
Drosophila melanogasterNCBITaxon:7227
chromatinGO:0000785
Variant set: ISWI-containing complexes (One Or More)
NURF complexProtein Complexnurf

Annotons

NURF complex
nurf_complex
Participant: Protein Complex: NURF complex
Protein Complex:
NURF complexGO:0016589
Active units:
Caf1-55
Participant: Gene Product: Caf1-55
Gene Product:
Caf1-55UniProtKB:Q24572
E(bx)
Participant: Gene Product: E(bx)
Gene Product:
E(bx)UniProtKB:Q9W0T1
Iswi
Participant: Gene Product: Iswi
Gene Product:
IswiUniProtKB:Q24368
Function:
ATP-dependent chromatin remodeler activityGO:0140658
Nurf-38
Participant: Gene Product: Nurf-38
Gene Product:
Nurf-38UniProtKB:O77460
Function:
inorganic diphosphate phosphatase activityGO:0004427
ACF complexProtein Complexacf

Annotons

ACF complex
acf_complex
Participant: Protein Complex: ACF complex
Protein Complex:
ACF complexGO:0016590
Active units:
Acf
Participant: Gene Product: Acf
Gene Product:
AcfUniProtKB:Q9V9T4
Iswi
Participant: Gene Product: Iswi
Gene Product:
IswiUniProtKB:Q24368
Function:
ATP-dependent chromatin remodeler activityGO:0140658
CHRAC complexProtein Complexchrac

Annotons

CHRAC complex
chrac_complex
Participant: Protein Complex: CHRAC complex
Protein Complex:
CHRAC complexGO:0008623
Active units:
Acf
Participant: Gene Product: Acf
Gene Product:
AcfUniProtKB:Q9V9T4
Chrac-14
Participant: Gene Product: Chrac-14
Gene Product:
Chrac-14UniProtKB:Q9V444
Chrac-16
Participant: Gene Product: Chrac-16
Gene Product:
Chrac-16UniProtKB:Q9V452
Iswi
Participant: Gene Product: Iswi
Gene Product:
IswiUniProtKB:Q24368
Function:
ATP-dependent chromatin remodeler activityGO:0140658
RSF complexProtein Complexrsf

Annotons

RSF complex
rsf_complex
Participant: Protein Complex: RSF complex
Protein Complex:
RSF complexGO:0031213
Active units:
CG8677
Participant: Gene Product: CG8677
Gene Product:
CG8677UniProtKB:Q9VID9
Iswi
Participant: Gene Product: Iswi
Gene Product:
IswiUniProtKB:Q24368
Function:
ATP-dependent chromatin remodeler activityGO:0140658
NORC complexProtein Complexnorc

Annotons

NORC complex
norc_complex
Participant: Protein Complex: NORC complex
Protein Complex:
NORC complexGO:0090536
Active units:
Iswi
Participant: Gene Product: Iswi
Gene Product:
IswiUniProtKB:Q24368
Function:
ATP-dependent chromatin remodeler activityGO:0140658
tou
Participant: Gene Product: tou
Gene Product:
touUniProtKB:A8DYA3
TORC complexProtein Complextorc

Annotons

TORC complex
torc_complex
Participant: Protein Complex: TORC complex
Protein Complex:
TORC complexGO:0031010
Active units:
CtBP
Participant: Gene Product: CtBP
Gene Product:
CtBPUniProtKB:O46036
Iswi
Participant: Gene Product: Iswi
Gene Product:
IswiUniProtKB:Q24368
Function:
ATP-dependent chromatin remodeler activityGO:0140658
tou
Participant: Gene Product: tou
Gene Product:
touUniProtKB:A8DYA3