The Drosophila JAK-STAT pathway has a minimal set of core components. The secreted Unpaired cytokines (Upd1, Upd2, Upd3) bind the receptor Domeless, which is related to vertebrate gp130-type cytokine receptors. Receptor activation stimulates the associated Janus kinase Hopscotch, which phosphorylates Domeless and the single STAT, Stat92E. Phosphorylated Stat92E dimerizes, enters the nucleus and activates target genes. The pathway acts in embryonic segmentation, stem cell maintenance, hematopoiesis, intestinal regeneration, cellular immunity and stress responses.
Boundary. Core components only (FlyBase JAKSTAT-C). The decoy receptor Latran, Socs36E, Ptp61F, Stat92E-interacting cofactors and other FlyBase regulators are not parts. FlyBase groups realized by this module: JAKSTAT (FBgg0000883). Subgroups folded into it: JAKSTAT-C. FlyBase also curates regulator sets for this pathway, which are context and not modelled as parts: JAKSTAT-P (positive regulators of jak-stat signaling pathway, 16 genes); JAKSTAT-N (negative regulators of jak-stat signaling pathway, 19 genes). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_jak_stat_signaling.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_jak_stat_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 6 evidence or coverage gap(s) (6 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| unpaired_cytokines_upd1 | upd1 UniProtKB:Q9VWW4 Gene |
receptor ligand activity GO:0048018 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| unpaired_cytokines_upd2 | upd2 UniProtKB:Q9VWX2 Gene |
receptor ligand activity GO:0048018 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| unpaired_cytokines_upd3 | upd3 UniProtKB:Q59E38 Gene |
receptor ligand activity GO:0048018 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| domeless_dome | dome UniProtKB:Q9VWE0 Gene |
cytokine receptor activity GO:0004896 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| hopscotch_hop | hop UniProtKB:Q24592 Gene |
non-membrane spanning protein tyrosine kinase activity GO:0004715 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| stat92e_stat92e | Stat92E UniProtKB:Q24151 Gene |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
0 complete review(s) · 0 with deep research · 7 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Stat92E Q24151 | ✗ | — | — |
| hop Q24592 | ✗ | — | — |
| upd3 Q59E38 | ✗ | — | — |
| Sarm Q6IDD9 | ✗ | — | — |
| dome Q9VWE0 | ✗ | — | — |
| upd1 Q9VWW4 | ✗ | — | — |
| upd2 Q9VWX2 | ✗ | — | — |
Unpaired cytokines activate Domeless and the JAK Hopscotch, which phosphorylates Stat92E to drive target gene transcription.
Sarm, a TIR-domain NAD(+) hydrolase, is listed by FlyBase among the core components; its position in the pathway is not established.