The Kip1 ubiquitination-promoting complex (KPC) is a heterodimeric E3 ubiquitin ligase first described in mammals, where the RING-finger protein KPC1 (RNF123) ubiquitylates substrates and KPC2 (UBAC1), a ubiquitin-like and UBA domain protein, links ubiquitylated substrates to the proteasome. Mammalian KPC promotes cytoplasmic degradation of the CDK inhibitor p27Kip1 in G1. Drosophila Kpc1 and Kpc2 are the orthologs of these two subunits.
GO has no specific term for the KPC complex, so the module is grounded to the generic ubiquitin ligase complex term. The functions of KPC are known from mammals; Drosophila substrates have not been established. Kpc1, the RING-domain subunit, is given ubiquitin protein ligase activity (GO:0061630, which it carries in GOA by ISS and IEA); Kpc2 is a UBL-UBA adaptor with no known catalytic activity and has no molecular function here. FlyBase groups realized by this module: KPC (FBgg0001735). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_kpc_ubiquitin_ligase.yaml. Member genes with a gene review in this repository: Kpc1, Kpc2.
All recommended fields populated.
✗ none found
No MODULE:dmel_kpc_ubiquitin_ligase deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| dmel_kpc_ubiquitin_ligase_kpc1_kpc1 | Kpc1 UniProtKB:Q9VFC4 Gene |
ubiquitin protein ligase activity GO:0061630 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
1 complete review(s) · 2 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Kpc1 Q9VFC4 | ✓ | ✓ | ✓ |
| Kpc2 A0A0B4KFW5 | ✓ | 7/8 | ✓ |
Heterodimer of the RING E3 ligase Kpc1 and the proteasome-shuttle subunit Kpc2.
RING E3 ligase subunit
ubiquitin-like and UBA domain shuttle subunit