Larval serum proteins (LSPs) are hexamerins, storage proteins related to arthropod hemocyanins that have lost the copper-binding oxygen-carrying function. They are made in large amounts by the larval fat body, secreted into the hemolymph, and taken back up by the fat body at the end of the third instar, where they are stored in granules and broken down to supply amino acids for metamorphosis. Lsp1 hexamers are made of the alpha, beta and gamma chains (Lsp1alpha, Lsp1beta, Lsp1gamma) in various combinations, and Lsp2 forms a separate hexamer.
No GO cellular component term specifically describes a hexamerin complex, so the module is grounded to the protein storage process instead; the parts are labelled as Lsp1 and Lsp2 hexamers. Lsp2 forms homohexamers and is modelled as a single-gene part. Lsp1 hexamers mix the three Lsp1 chains in several combinations; the exact subunit stoichiometries are not modelled. Receptor-mediated uptake of LSPs by the fat body at the end of larval life is outside the module. Lsp2 is also expressed in the adult fat body. FlyBase groups realized by this module: LSP (FBgg0001752), LSP1 (FBgg0001781). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_larval_serum_protein_hexamers.yaml. Member genes with a gene review in this repository: Lsp1alpha, Lsp1beta, Lsp1gamma, Lsp2.
All recommended fields populated.
✗ none found
No MODULE:dmel_larval_serum_protein_hexamers deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (2 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| lsp1_hexamer_complex | PROTEIN_COMPLEX Gene |
nutrient reservoir activity GO:0045735 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
| lsp2_hexamer_lsp2 | Lsp2 UniProtKB:Q24388 Gene |
nutrient reservoir activity GO:0045735 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
4 complete review(s) · 4 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Lsp1alpha P11995 | ✓ | ✓ | ✓ |
| Lsp1beta P11996 | ✓ | ✓ | ✓ |
| Lsp1gamma P11997 | ✓ | ✓ | ✓ |
| Lsp2 Q24388 | ✓ | ✓ | ✓ |
Fat-body-made hexamerin storage proteins (Lsp1 and Lsp2 hexamers) that supply amino acids for metamorphosis.