LKB1 is a serine/threonine kinase that is active only when bound to the pseudokinase STRAD (Stlk in Drosophila) and the scaffold MO25. The trimeric complex phosphorylates the activation loop of AMPK and of AMPK-related kinases such as Par-1, and so acts as a master upstream kinase. In Drosophila, Lkb1 is required for anterior-posterior polarity of the oocyte, for epithelial polarity under energy stress, and for asymmetric division of neuroblasts.
No specific GO cellular-component term exists for this complex, so it is grounded to the parent serine/threonine protein kinase complex term. The activation mechanism is best characterized for the human complex. FlyBase groups realized by this module: LKB1C (FBgg0001919). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_lkb1_strad_mo25_complex.yaml. Member genes with a gene review in this repository: Lkb1, Mo25, Stlk.
All recommended fields populated.
✗ none found
No MODULE:dmel_lkb1_strad_mo25_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| dmel_lkb1_strad_mo25_complex_lkb1_lkb1 | Lkb1 UniProtKB:Q8T9L5 Gene |
protein serine/threonine kinase activity GO:0004674 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
2 complete review(s) · 3 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Lkb1 Q8T9L5 | ✓ | 38/43 | ✓ |
| Mo25 P91891 | ✓ | ✓ | ✓ |
| Stlk P83098 | ✓ | ✓ | ✓ |
Heterotrimeric master kinase of AMPK and AMPK-related kinases, formed by the kinase Lkb1, the pseudokinase Stlk and the scaffold Mo25.
catalytic kinase subunit
MO25 scaffold
STRAD pseudokinase activator